“Long-term treatment with ABT-263 or D + Q, initiated in middle-age [rats], decreased peripheral markers of tissue senescence and systemic inflammation, and preserved hippocampal-dependent cognitive function and NMDAR-mediated synaptic transmission […]”
“The results indicate that preserved cognition was associated with the removal of peripheral senescent cells, decreasing systemic inflammation […]”
“Rats were treated via oral gavage for 5 consecutive days with a 2 week break in between two cycles […]. A total of eight cycles of treatment over the span of 6 months were administered before the rats were behaviorally characterized for motor and cognitive performance. […]”
Full Text:
https://onlinelibrary.wiley.com/doi/10.1111/acel.13817
Citation:
Budamagunta, V., Kumar, A., Rani, A., Bean, L., Manohar-Sindhu, S., Yang, Y., Zhou, D., & Foster, T. C. (2023). Effect of peripheral cellular senescence on brain aging and cognitive decline. Aging Cell , 00, e13817.