So - for the dermatologists here, does this suggest that D-Mannose used topically might help mitigate age-related skin disfunction / degeneration?
Here, we found that topical supplementation of D-mannose remarkably attenuated skin lesions and recovered skin barrier function in AD mice model induced by DNCB. Furthermore, in vivo and in vitro experiments indicated that D-mannose inhibited tumor necrosis factor-α (TNF-α)-mediated increased expression of inflammatory cytokines. D-mannose also markedly downregulated TNF-α-stimulated activation of mTOR/NF-κB signaling pathway that was crucial for regulating the inflammatory condition. However, these effects were abolished by treatment with inhibitors of mTOR or NF-κB in HaCaT and NHEK. As far as we know, this is the first study uncovering the effective role of D-mannose via skin topical application. We found that D-mannose plays a regulatory role on inflammatory keratinocytes, suggesting its therapeutic utilization as a potential drug against atopic dermatitis.
I have started taking D-Mannose to prevent UTI while on Canagliflozin.
I have multiple sclerosis so am prone to UTIs, even as a male.
I subsequently discovered the wonderful world of D-Mannose as I felt 10 years younger within 15 minutes of taking. Apparently it is very good for MS, muscle growth and even hair loss: