FYI, the link shows the target $ has been met and no more donations are accepted. I guess this is great news!
The first half of the molecules. I believe there is a second fundraiser they are doin to test the other 300. But it’s a great start for sure.
@Beth @AustraliaLongevity @RapAdmin Thanks for highlighting this! Ora biomedical has now launched the fundraising page for the second subproject where the rest of the mTOR inhibitors will be screened.
This link should now work: Rapamycin Longevity Labs Fundraising Campaign (mTOR inhibitors #2) – Ora Biomedical, Inc.
Big thanks for all the support!
PS. Around two months from now we will get big magnitude of lifespan data for the first 301 mTOR inhibitors.
I already see some contributions. Did this happen last night? That’s great.
Yes, I shared the link with one person who was interested in helping out and then Rapamycin Longevity Lab made a contribution. Next week on Tuesday my plan is to make a announcement in social medias that the fundraising for the second subproject has started 
Very exciting. It’s good to take advantage of the momentum of the excitement that the first half of the fundraiser is done and the results will be coming in, in the next 2-3 months.
Latest status of the fundraising of the second subproject
We’re thrilled to announce that we’ve reached 28% funding for our second subproject, where we’ll screen the remaining 300 mTOR inhibitors! The goal is to uncover the next breakthrough beyond the mTOR inhibitor Rapamycin, which is currently the most promising longevity compound due to its effects across multiple species. But there are likely even more potent longevity compounds waiting to be discovered and that’s exactly what this project is all about!
A massive thank you to everyone who has contributed so far and especially to Anonymouse for the latest generous $10K contribution to the second subproject! All this support is making a real difference in advancing longevity research and generating unique data that no one else has delivered to the field before. This large dataset will be publicly available for everyone, providing an important foundation for labs, researchers and AI to progress beyond basic studies toward more advanced and impactful longevity research.
If you’re passionate about longevity or want to help make a difference, we’d love for you to get involved in this historical project! Whether through sponsoring, sharing the social media posts (LinkedIn, X) or even just give them a thumbs up. Every action helps to move the needle forward. Let’s make this happen together!
Data from the first half will give a lot of positive publicity to this fundraiser if the fundraiser is not completed before that time.
There are a LOT of interesting molecules in this study.
Yes, I fully agree, will be very interesting to see what new findings we as a field will do thanks to this project. The latest I have heard from Ora is that things point towards that there are compounds which show increase, no effect or even decrease in lifespan. All these data points will be super interesting to deep dive in.
@Krister_Kauppi i contributed and then read this thread
Is there a way to give a donation to foundation such that one can get a tax write-off
That would help people feel good about it being a pure donation.
Big thanks for the contribution, @Neo! It’s a very good question around tax rights! I know in Sweden where I live they have the possibility of tax deduction for gifts somehow but I’m not sure how it works when it comes to gifts given to a party in another country. I will check that. For US citizens then it’s possible to get it. I will add more info on that in the project white paper and on the fundraising page. Thanks for highlighting this!
The MMC has had this on site for a long time:
Not clear that this partnership has ever been operationalized. I looked around lifespan.io and couldn’t find a way to do anything specific to Ora. Maybe @Mitchell_Ora can explain how this is supposed to work.
Not clear how a 501c3 can route money into a presumably for-profit Ora Biomedical. But it seems to be possible.
This is a text I got from lifespan.io
Ora Biomedical is proud to partner with Lifespan Research Institute, a U.S.-based nonprofit that serves as the fiscal sponsor for the Million Molecule Challenge. This scientific initiative aims to identify compounds that may extend healthy human lifespan. The partnership enables tax-deductible donations to be made via Lifespan.io, with contributions designated to support the Million Molecule Challenge through this fiscal sponsorship.
If someone is interested in contributing to the mTOR inhibitor project then reach out to me and I will put you in contact with the contact person at lifespan.io who will make it possible to enable a tax-deductible donation for people in the US.
PS. I have now also updated the project white paper with information about it.
If we can get donations tax deductable in other countries that would be fantastic.
I just put $100 in.
Big thanks for the support @AustraliaLongevity Could you check what rules there are in Australia around taxes and donations? Because I think it will differ between countries.
I think you probably need a charity registered in a particular country to get a tax benefit (counting the EU as a single country from this perspective).
Please help out in amplifying the social media posts so that we increase the chance of getting the project fully funded.
https://x.com/KristerKauppi/status/1945062001274708269
The social media post
This is the day I have been waiting for and it’s time to start to release preliminary data from the first phase of the lifespan screening of 301 of 601 compounds in roundworms. Below is the current top list of the 37 compounds. Out of the 301 compounds tested 5 have produced a higher median lifespan extension than than the best recorded lifespan of Rapamycin which is 27%.
My three key takeaways from this is
-
When I started to look deeper at the compounds in the top list I was surprised that there were 3 compounds that indirectly activated mTOR instead of inhibiting it. This unexpected result turned out to be fortunate because the goal was to screen 601 mTOR inhibitors and not look at mTOR activators. It’s still early data but this challenges the assumption that mTOR activators would be connected to a decrease in lifespan. It’s very interesting data points that we have provided to the field and more research is of course needed here to understand why they seem to work and if it translates to other species as well. Due to all this a decision has been taken to change the project name from “Rapid lifespan analysis of 601 mTOR inhibitors” to “Rapid lifespan analysis of 601 mTOR modulators” to better reflect the scope. It is also good to point out that most of the compounds are mTOR inhibitors in the library according to the chemical company provider.
-
It was discovered that the ATP-competitive mTOR kinase inhibitor PQR626 has lifespan extension properties that is better than Rapamycin. This is interesting because this compound targets both mTORC1 and mTORC2 unlike Rapamycin which targets directly mTORC1. This, and other data in the top list, challenges a bit the current view that mTORC1 inhibition is connected to lifespan and mTORC2 is connected to decrease in lifespan. Additional validation in other species such as mice will be key here. The goal is to send in proposals to both ITP and CITP next year for testing the PQR626 compound. Proposals for testing Omipalisib were submitted earlier this year.
-
Every compound in this screen was tested at just one dose. That means potential for further lifespan extension if the dose is optimized. We will test different doses of both PQR626 and Omipalisib to see if we can optimize them even more. If someone is interested in testing any of the compounds that have been screened in other species or strains please reach out. Let’s collaborate!
PS 1. Ora Biomedical is validating the rest of the data and when this is done it will be published to their database and Rapamycin Longevity Lab LID database.
PS 2. Funding Need: We’re still seeking $28600 to finish screen of the remaining 300 compounds. If you’d like to support then please reach out to me!
I’d love to hear any information people on this website have on these compounds, particularly the ones above the red line.
It seems these are investigational new compounds that have limited human testing so far… so still very early in the process and not something I’d be looking at for personal consumption any time soon.