“Complementary longitudinal epigenetic clock analyses of 36 participants prior to and following Pfizer and Moderna mRNA-based COVID-19 vaccination revealed that vaccination significantly reduced principal component-based Horvath epigenetic clock estimates in people over 50 by an average of 3.91 years for those who received Moderna.”
This is interesting. I received the Moderna vaccine plus 2 boosters.
Medcram posted about this on X.
Hmmmm…buyers remorse? Had Pfizer shot twice… booster twice. Got Covid… was nothing. Skipping any future Covid shots. My TruMe Labs epigenetic methylation test went up about 2 years… 50 years to 52 years.
This month had RSV, pneumonia, shingles and regular flu shot. No reaction to any of the vaccines… rapamycin might be helping.
This study is just retrospective bullshit, nothing more. I cannot even identify how they collected the sample data for all we know they just selected samples that showed what they wanted to show
The Study Cohort
Deidentified DNA methylation data were generated by TruDiagnostic as part of a retrospective non-randomized study
Participants were healthy (n = 14M, 7F) and ranged in chronological age from 18 to 73 years (Median = 46 years)
21 participants, seriously!
There are others papers, including in top journals on the topic too though:
Found these two papers referenced in the paper above interesting:
www.nature.com/articles/s41467-022-29801-8
See eg
“mRNA-based COVID-19 vaccination revealed vaccination significantly reduced principal component-based Horvath epigenetic clock estimates in people over 50 by an average of 3.91 years for those that received Moderna”
New pre-print found T-cell exhaustion and prolonged spike protein production in some COVID vaccine recipients - with spike levels increasing over time.
To me, all of these studies tell us more about limitations of these epigenetic clocks. They’re affected by many things, and I don’t think they have much value.
For example, smoking cigarettes affects the clock, and they need to factor this in, otherwise smoking can make you test as younger… (got this from Steve Horvath himself)
People who have been hospitalized with severe COVID-19 infection can exhibit brain changes that cause the equivalent of 20 years’ worth of aging, significantly impacting their cognition. The findings of a new study, the largest of its kind in the UK to date, show how neurological complications can persist in these patients long after their respiratory symptoms have resolved.
The study is published in Nature Medicine.