Concepts of Aging - Circa 1931

Old blood affecting young cells has been around since then… And more.

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Thomas Samuel Gardner did a lot of interesting research in the 1940s and 50s that is worth reading.

This paper

Which found an extension of lifetime of Mice from Yeast Nucleic Acid I think is through the mechanism of assisting the transcription of longer genes. (because it happens slightly faster on average fewer of the RNA II polymerase complexes are terminated early.)