Combination of rapamycin and metformin, wherein the molar ratio of rapamycin to metformin

“Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases”

…“composition including a combination of rapamycin and metformin, wherein the molar ratio of rapamycin to metformin is in the range of about 20:1 to about 1:1; 10:1 to about 4:1; 5:1 to about 3:1; or about 5:1 to about 4:1. The composition may be formulated for oral administration, topical administration, parenteral administration, etc.”…

Shamelessly copying!


Seriously… put two medications together and call it something new… Secret Medication. Lol

Ketsup , mustard, mayonnaise and relish = Jack in the Box …Secret Sauce. Need a patent.


It is tried all the time.

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I had a colonoscopy yesterday and every medical staff I spoke with asked about me taking metformin off label. They were very intrigued but never heard of it’s off label use.

No question about Sirolimus!

Gotta fist bump from my gastro doc when I told him why :fist_right: :fist_left:

Colonoscopy results were normal, no polyps or other issues.


Patrick, I’m just curious. Do you mind stating your particular reason for taking metformin off-label. Thanks.

I started taking it in October 2021 after listening to dr Sinclair and many others discuss its benefits for cellular health and MTORC1 inhibition.

When I first started metformin I cut my portion sizes in half, I was full faster. That isn’t the case now a year later.

I went from 185 to 165lbs from October to February, I was at 11% body fat and at my high school weight. I’m now around 176 and I believe that is because I worked on getting my total testosterone to above 750.

Probably also why I’m eating more.

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Is the combination an appetite suppressant? A friend of mine says it is. I haven’t noticed effects but maybe I could try 1500mg/day metformin

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I have had great success with metformin as an appetite suppressant.

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If you were a mouse, you could hope to extend your life by 25% with a combination of rapamycin and metformin. Perhaps more, but the research hasn’t tested that yet.

If you are a human…

I think these are things to test. It starts to be well advanced science that goes far beyond mice, with drugs that are taken by millions of patients every year — with Josiah Agboluwaga Akinloye and

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Peut être une image de ‎texte qui dit ’‎۔gnif %in 17% 14 ITP-UM;M;C2005;Rapa_ 1024 17% 104 897 14% 1086 810 1053 126 126 4% 1031 1140 1001 1000 88 88 120 8% 829 1062 25% mo, 87 1092 96 100 1056 52 857 20 1193 14% 15% TP-UT:F:C2015;Rapa 1077 99 891 20 9% 1120 41% 738 TP-UM;F;C2015;Rapa 1040 102 99 1065 897 12% ppm 904 1026 11% 92 92 1039 6% 1079 928 904 979 4% 96 ITP-UM;M;C2015;Rapa_stop stop 10% 19% 1% 1031 738 794 3% 881 891 99 99 1062 1031‎’‎

International Longevity Alliance

Edouard Debonneuil · ·

If you were a mouse, should you take rapamycin? at what dose, intermittently or continuously, and starting when? Should you also take metformin? Here is what the data says, to increase lifespan by about 25% if you are a mouse – not so bad!

Context: as part of the COLLIDA project (please anyone is welcome to participate - Collective Collection of Lifespan Data, and consequent analysis), with Leon Pesha we started by collected the data about rapamycin from the NIA Intervention Testing Program (ITP) and to analyze it, while having a view on whether the controls are coincidentally short- or long- lived (an aspect generally forgotten, but that plays a big role in interpretations especially in males cages – more to come soon on this, but for now you can look at the colors on column “median control” to understand, and as a teaser I can sadly say “berberine” and “fisetin”…)

Result: regarding rapamycin, if you were a mouse,

  • use a low-to-medium-dose!: 14 or 42 ppm : it is not clear that 42 ppm is better and 14 seems even slightly better — so no need to try high doses, it might do more harm than good

  • long-term-use for much better results!:

the short term use when retired and still healthy (from month 20 to 23) provides a NON-significant increase despite many mice (last 6 lines of the picture; the appearent statisticant increase in males at the bottom is ONLY due to coincidental short-lived controls – males fight I can guess)

  • OK to start at retirement!:

the difference is very slim with starting at young adulthood, so this is perhaps the good news for many mice 🙂

  • intermittently is OK, though it is not as efficient as contant.

A good news for safety (no detrimental rebound effect)

  • +metformin, yes!:

despite lower median lifespan of all controls in the 14ppm rapamycin + 1000ppm metformin 2015 experiment than in the same experiment without metformin in 2006, all treated groups had a longer lifespan than their counterparts without metformin. On average, rapamycin increased lifespan by 10-15% and metformin too! At a time when doubts are emerging about metformin, this is good news, at least in association with rapamycin.

Important disclaimer: do not take rapamycin and metformin on your own, consult your medical doctor. Even though rapamycin studies by the ITP in non-human primates suggest similar medium term actions and even though numerous patients were given rapamycin at high doses and even if the above studies were done in humans, anyone may have undesirable side effects.

Next?: we are going to explore the rest of the ITP data and start exploring non-ITP data, to help guide research on what to test next as a non-ending, practical, efficient guide for healthy life extension research (COLLIDA project). For non-ITP data, we need your help! It is a project that can be distributed across many people who give a few hours of time.