It seems that there may be some good reasons to believe that rapamycin and metformin help slow skin aging…
Major clinical evidence of calorie restriction and intermittent fasting on skin health: a systematic review
(Click on the above title link for download of full PDF of paper).
MS Rocha, FN da Silva Koslinski, LL de Aquino… - MedNEXT Journal of …, 2023
The anti-inflammatory, antioxidant, stem cell maintenance, and metabolic activities of calorie restriction contribute to its beneficial effects on the skin. Calorie restriction mimetics, including metformin, rapamycin, and peroxisome proliferator-activated receptor agonists, show similar prevention to calorie restriction against skin aging [17].
Conclusion
It was concluded that although calorie restriction is the most effective intervention to prolong the life of organisms and prevent age-related diseases, its effects on aging and skin diseases can be significant. Dietary lifestyles can affect epithelial lineages such as the skin and intestine. The impact of Ramadan fasting on skin health can be compared with the effect of other types of fasting, including periodic dieting, calorie restriction, dietary restriction, dietary manipulation, and intermittent, short-term, and prolonged fasting. However, despite the scarcity of studies on the topic, no serious health risks have been reported and, therefore, patients who wish to fast should be warned about the importance of continuing their treatment and the administration of transdermal/topical medications.
And, another related paper on skin health:
Research Progress in Skin Aging, Metabolism, and Related Products
Abstract
In recent years, skin aging has received increasing attention. Many factors affect skin aging, and research has shown that metabolism plays a vital role in skin aging, but there needs to be a more systematic review. This article reviews the interaction between skin metabolism and aging from the perspectives of glucose, protein, and lipid metabolism and explores relevant strategies for skin metabolism regulation. We found that skin aging affects the metabolism of three major substances, which are glucose, protein, and lipids, and the metabolism of the three major substances in the skin also affects the process of skin aging. Some drugs or compounds can regulate the metabolic disorders mentioned above to exert anti-aging effects. Currently, there are a variety of products, but most of them focus on improving skin collagen levels. Skin aging is closely related to metabolism, and they interact with each other. Regulating specific metabolic disorders in the skin is an important anti-aging strategy. Research and development have focused on improving collagen levels, while the regulation of other skin glycosylation and lipid disorders including key membrane or cytoskeleton proteins is relatively rare. Further research and development are expected.
Full (open access) Paper: