Repair of DNA double-strand breaks leaves heritable impairment to genome function
Cells organize their DNA in a three-dimensional structure that helps control which genes are turned on or off. Bantele et al . investigated whether this structure fully recovers after DNA damage is repaired. The researchers introduced precise DNA breaks and tracked changes in genome organization and gene activity. They found that even after the DNA was repaired, the affected regions remained misfolded and showed reduced gene expression, and these changes were passed on to daughter cells. DNA damage thus leaves lasting marks on genome function, a phenomenon called “chromatin fatigue,” which has important implications for aging, disease, and gene-editing technologies such as CRISPR. —Di Jiang
https://www.science.org/doi/10.1126/science.adk6662
I remember David Sinclair talking about this in the 2018 GSA meeting