A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00298-X
Cracking gastric cancer’s metabolic code: Blocking cholesterol pathways slows tumor growth by 65% in mice
https://medicalxpress.com/news/2025-11-gastric-cancer-metabolic-code-blocking.html
“The study reveals that these enteric neurons increase gastric cancer cells’ reliance on lipids (i.e., fatty acids and cholesterol) for survival. When cancer cells are infiltrated by neurons, targeting this metabolic vulnerability with cholesterol pathway inhibitors can enhance cancer cell death by 6.3 times.
This discovery opens new avenues for developing personalized therapies for gastric cancer.“