Almost nobody exercises too much.
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Of all the risk factors for hastening death, that is the one I worry least about.
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Is there much point in eating more just to need to exercise more to burn it off?
Exercise for cardio fitness or muscle strength is different.
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Well again, who does that? A very small minority of people not worth talking about.
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A lot of people, consciously or unconsciously. I work with a guy who exercises specifically to justify eating more.
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Hahaha…with more muscle mass…I need more calories it seems… and rapamycin has me pretty shredded. So, I eat constantly… guilt and fat free. If there is food available…I eat it. S
I am staying at 188 to 190 pounds for some time. I weigh myself before hopping in the shower each morning.
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That’s cool. How long on rapamycin before you started seeing these benefits?
When I take a 1 week break I tend to feel really good the first 1-4 days after dosing, unless I get a mouth sore which kinda ruins it. I’m hoping to get to once a week dosing once I find away around mouth sores which I think is related to taking too many CYP3A4 inhibiting supplements. I’m looking to replace berberine with metformin SR and occasional acarbose, and citrus bergamot with ezetimibe and either bempedoic acid or pravastatin.
For me tirzepatide and TRT seem to give similar results. TRT alone was great for improving mood and energy but when I threw tirzepatide on top of that I just had this switch in my mind and I eat to live instead of live to eat about 95% of the time. I can enjoy simple meals without feeling like I require novelty.
Before tirz I required a lot more conscious discipline. GLP1 agonism is like willpower in a drug.
I see you take acarbose. I’m thinking of including this in my regimen when I consume starchy meals. Is that how you use it?
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Yes… using acarbose mainly for carbs. When full meat… protein…I skip.
As to shredding. For me, fat was being used as fuel started at the end of 3 months… about day 90 of dosing.
My weight was close to 200 pounds…I lost a pound… then a few more days another and by 2 months had lost about 20 lbs. Taking my weight to 180 pounds.
No loss of muscle in the process. Once visceral fat was gone.(proven by a DEXA body fat scan) weight loss stopped.
Maintaining all the good stuff… muscle mass and bone density and health. That was 4 years ago… as an early adopter of rapamycin.
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Did it happen because of Rapamycin? What was the dose?
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Yes… was the rapamycin. Dose 6 mg weekly. No GFJ.
I had lost as much as I could… and was maintaining the same weight and body mass size for 2 years. The fat I mostly lost was undetectable visually. It was my visceral fat around my organs. Once it vanished, I was still the same mass only suddenly abs appeared and cut adonis belt lines. And, still have abs and belt 4 years later… but I don’t do ab exercises like sit-ups or crunches.
I guess, if I did those kinds of exercises I would be even more chiseled
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Visceral is the worst fat of all.
It sounds like an experiment is in order.
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Stupid question alert:
Is there any way to lose visceral fat aside from losing weight? I still have some, but at the moment, I have no more weight to lose
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Agetron said he experienced visceral fat loss from rapamycin and acarbose. I’m pretty sure I’ve experienced this with tirzepatide (haven’t done DEXA scan but my stomach is flatter), I think the GIP agonist part of it directly burns fat including visceral fat.
I’d be curious what other methods people have, as visceral fat is so important to cut back on.
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Sorry for not being clear-er… the lost weight I had was the visceral fat. My size and muscles remained the same… so the lost weight was adipose tissue… definitely not needed weight. Lol.
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Ha! You were plenty clear, I did understand and realize you are a lucky genetic freak 
I’d hate you if you were not so like-able
@AustraliaLongevity sounds like gip can help me lose visceral… I do take that on occasion, but it’s not too often as my weight is bordering on too low these days. I will try to increase the frequently and just eat through it so I can maintain my weight and hopefully lose more of my visceral fat. I already take rapa and acarbose.
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You will have more success on viscral fat with a glp1 medicine that also targets glucagon: retatrutide, mazdutide, survodutide. These provide excellent reduction of liver fat: over 50% at higher doses for mazdutide:
The numbers for retatrutide are even more effective.
Tesamorelin is another option. It is really effective at reducing abdominal fat, it is prescribed to AIDS patients that suffer from HIV-associated lipodystrophy. Tesamorelin will not induce appreciable weight loss.
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Hi @Beth
Before rapamycin I tried gynnostemma pentaphyllum tea.
When in combination with time restricted feeding I lost more visceral fat from that. than I have done with any other natural products, including berberine. Fat loss due to berberine, was more evenly distributed over my body than the fat loss I got from gynnostemma tea.
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If you @Beth decide to try the tea, make it really strong and drink at least 500 ml of strong tea each day.
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I’ve heard good things about gynostemma. Something I’ve been thinking about in regards to herbal medicine is we should really be breaking down which phytonutrients within these herbs are causing the most benefit.
For instance I did a breakdown of cabbage and here is what I found:
Cabbage phytonutrients that had positive results from DrugAge database:
- Gallic acid
- Chlorogenic acid
- Procyanidins
- Myricetin
- Isorhamnetin
- Caffeic acid
- p-Coumaric acid
- Protocatechuic acid
- Sulforaphane
Cabbage Phytonutrients that have no data in DrugAge database:
- Sinigrin
- Glucoraphanin
- Glucobrassicin
- 4-Methoxyglucobrassicin
- 4-Hydroxyglucobrassicin
- Neoglucobrassicin
- Glucoiberin
- Glucoiberverin
- Glucoalyssin
- Glucoerucin
- Progoitrin
- Gluconapin
- Glucobrassicanapin
- Ferulic acid
- Sinapic acid
- Vanillic acid
- Syringic acid
- p-Hydroxybenzoic acid
- Zeaxanthin
- Violaxanthin
- Neoxanthin
- Indole-3-carbinol
- 3,3′-Diindolylmethane
- Allyl-isothiocyanate
- S-Methyl-L-cysteine sulfoxide
There are a lot of interesting things out there still to discover.
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Why are the Wellness Elite Getting Sepsis? | Mark Hyman and Jordan Peterson
I. Executive Summary
This investigative report by journalist Scott Carney exposes the serious translational gaps, safety risks, and regulatory circumventions occurring at the intersection of medical social media influence and international regenerative medicine. The central thesis is that the lack of transparency surrounding medical complications in the wellness industry places the public at severe risk. When prominent wellness figures suffer near-fatal consequences from the unverified therapies they promote, they often obscure these failures to protect their commercial brands and supplement pipelines.
The primary case study centers on Dr. Mark Hyman, a leading figure in functional medicine and longevity who has frequently claimed an optimized biological age far below his chronological timeline. The report pieces together Hyman’s unannounced mid-2024 to early-2025 public disappearance, linking it to a life-threatening case of spinal abscess and subsequent systemic sepsis that required an emergency surgical intervention at UCSF.
By cross-referencing deleted podcast files, internet archives, and deleted social media entries, the investigation reveals a direct correlation between Hyman’s spinal infection and invasive stem cell procedures performed at a clinic in Los Cabos, Mexico. The facility is operated by Dr. Adil Khan of Eterna Health, a well-known regenerative provider to high-profile figures.
The procedure involved epidural and facet joint injections of unapproved, synthetic, or manipulated biological products: specifically, umbilical-cord-derived “Muse” stem cells and engineered exosomes. These unvetted biological matrices carry high risks of microbial contamination, severe immune hyper-reactivity, and unregulated cellular proliferation.
The report highlights a systemic conflict of interest in the wellness landscape: Hyman and Khan were actively planning a joint business venture in Abu Dhabi while producing promotional media content for these exact therapies. Following his near-fatal medical emergency, Hyman systematically deleted the promotional interviews from all public feeds, concealing the dangerous reality of his treatment from his audience.
Carney expands this critique to the broader “griverse,” connecting it to secondary medical complications observed in other figures, including Jordan Peterson. Ultimately, the investigation serves as a critical warning against navigating unregulated offshore medical tourism, highlighting that non-standardized biological injections frequently bypass safety controls and can convert longevity protocols into catastrophic clinical outcomes.
II. Insight Bullets
- The Transparency Deficit: High-profile health influencers frequently use curated biometric metadata to market longevity pipelines, but they systematically hide severe medical complications to preserve their commercial relevance [[03:36], [03:44]].
- Offshore Regulatory Evasion: Prominent regenerative clinics operate primarily in jurisdictions like Mexico, Dubai, and Lithuania to bypass strict FDA safety standards, deploying experimental biological therapeutics that lack standardized human safety profiling [[01:47], [01:55]].
- The Spinal Abscess Cascade: Invasive epidural or intra-articular spinal injections bypass the body’s natural anatomical barriers; introducing non-sterile needles or contaminated biological matrices into these enclosed spaces can drive rapid bacterial proliferation and spinal abscesses [[11:08], [11:37]].
- Systemic Sepsis Pathophysiology: Left unchecked, a localized deep-tissue infection can quickly compromise vascular barriers, leaking pathogens into systemic circulation to trigger severe sepsis, organ failure, and high mortality risks [[13:02]].
- The “Muse” Stem Cell Framework: Regenerative marketing promotes engineered “Muse” stem cells and umbilical-cord-derived exosome matrices for their high potency and tissue differentiation; however, these claims rely on unverified, non-reproducible clinical frameworks [[16:47], [16:59]].
- Media Scrubbing Actions: Following his near-fatal medical emergency, Hyman systematically wiped a November 2024 promotional podcast with Khan from all public servers and internet feeds to eliminate evidence connecting his infection to the Cabo clinic [[18:15], [18:42]].
- Commercial Conflict Inversion: Influencers who maintain financial stakes in offshore clinical expansions (such as Hyman and Khan’s planned corporate partnership in Abu Dhabi) face massive financial incentives to actively hide adverse patient events [[20:15], [20:33]].
- The Influencer Ethics Exception: While standard patient histories are protected by absolute HIPAA privacy laws, public medical professionals who use their personal health claims to sell millions in supplements face an ethical obligation to disclose their clinical failures [[21:32], [21:52]].
- Unregulated Angiogenesis Risks: Injecting unvetted stem cell fractions and concentrated exosome vesicles carries an unquantified risk of driving rapid, off-target tissue changes or accelerating subclinical tumor growth via unregulated angiogenesis [[05:27], [22:14]].
- The Alopathic Care Intervention: When experimental wellness procedures result in systemic failure, patients are consistently forced to rely on traditional, advanced allopathic hospital systems (such as emergency neurosurgery at UCSF) to survive [[12:37], [13:34]].
- Hype vs. Age Reality: Longevity marketing claiming that a 66-year-old individual possesses a “biological clock of 25” represents unscientific, heavily manipulated metadata that is directly contradicted by normal physical aging metrics [[00:00], [07:38]].
- Chronic Pain Evasion Traps: Long-standing spinal pathologies like severe canal stenosis or facet arthritis often drive desperate patients to pursue unvetted, high-risk regenerative procedures outside traditional medicine [[11:02], [16:33]].
- Corporate Threat Responses: Unregulated regenerative clinics frequently use aggressive legal teams and threatening public statements to suppress independent media investigations that look into their patient safety records [[05:12], [05:19]].
- The Shared Provider Network: The interconnected nature of the wellness elite is highlighted by their reliance on a small network of fringe providers (such as Dr. Adil Khan), linking the medical complications of highly diverse public figures [[01:41], [01:47]].
IV. Actionable Protocol
High Confidence Tier (Backed by Level A/B Human Evidence)
- Utilize Standard Sterility-Controlled Facilities: Ensure that any invasive spinal or intra-articular injection (such as epidural steroid shots or nerve blocks) is performed exclusively within a fully certified alopathic medical hospital or surgery center. These facilities adhere to strict sterility protocols to minimize the risk of introducing deep-tissue bacterial infections [[11:08], [13:34]].
- Prioritize Emergency Allopathic Care for Sepsis Signs: If you undergo any needle-based intervention and subsequently develop a rapid fever, severe localized pain, or a sudden inability to walk, bypass alternative medicine clinics completely. Seek immediate emergency evaluation at a world-class trauma hospital to intercept potential systemic sepsis [[11:37], [13:02]].
Experimental Tier (Regenerative Concepts Requiring Extreme Caution)
- Audit the Quality Controls of Stem Cell Sources: If you are exploring regenerative medicine for chronic disc degeneration, demand full, transparent documentation regarding cell processing, batch sterility, and heavy metal testing. Avoid clinics that refuse to disclose their detailed laboratory protocols [[20:47], [20:53]].
- Maintain Strict Separation Between Commercial Hype and Clinical Fact: Do not base your medical decisions on celebrity endorsements or promotional podcast content. Thoroughly evaluate any unapproved or offshore biological therapy against independent, peer-reviewed clinical data before participating [[01:55], [21:52]].
Red Flag Zone (Claims Lacking Safety Data or Mechanistically Refuted)
- Avoid Unregulated Offshore Stem Cell Injections: Absolutely refuse to travel to offshore medical tourism destinations (such as unvetted clinics in Mexico or Dubai) for epidural or joint injections of manipulated “Muse” stem cells or concentrated exosome vesicles. These therapies bypass FDA safety controls and carry significant risks of severe microbial contamination and spinal abscesses [[01:47], [16:54]].
- Reject Biological Age Reduction Marketing: Disregard statements from influencers claiming they have reversed their biological clock down to age 25 or 39 while managing severe, active tissue degeneration. These numbers rely on heavily manipulated or highly selective metadata designed to sell product pipelines [[00:00], [07:38]].
- Avoid Clinics Managed by Providers Blocking Safety Audits: Steer completely clear of regenerative medical practices that hide their patient complication records or use legal threats to suppress independent media transparency. An elite client roster is not a valid proxy for human safety or sterile clinical practice [[01:55], [05:19]].
V. Literature Verification & Methodological Context
The serious risks exposed in Scott Carney’s investigation regarding invasive alternative biologics align closely with established infectious disease and neurosurgical literature.
- Infectious Risks of Epidural Interventions: The development of a deep spinal abscess following an unverified epidural injection is a well-documented clinical disaster. Neurosurgical literature confirms that introducing non-sterile needles or non-standardized biological materials into the epidural space can introduce aggressive pathogens like Staphylococcus aureus, triggering rapid epidural abscess formation, spinal cord compression, and subsequent systemic sepsis (Grewal et al., 2006).
- Unapproved Stem Cell Tourism Harms: The safety risks of unregulated stem cell and exosome clinics in jurisdictions with loose oversight are a major focus of global regulatory warnings. Position statements from the International Society for Stem Cell Research (ISSCR) and the FDA highlight that offshore medical tourism entities frequently deploy unapproved, poorly characterized cell fractions. These therapies carry high risks of severe bacterial contamination, dangerous host immune reactions, and the potential development of off-target proliferative masses (Marks et al., 2017).
- The Translational Disconnect in Exosome Therapy: While regenerative marketing praises exosome vesicles for their cell-signaling potential, clinical data regarding their safety in human spinal spaces remains entirely uncharacterized. Independent evaluations confirm that without strict standardization of vesicle isolation and purity, injecting concentrated exosomes can unintentionally trigger severe systemic inflammatory responses or promote tumor growth via unmonitored angiogenesis pathway stimulation (Mendt et al., 2019).
Methodological Caveat: While small-scale preclinical evaluations can indicate that specific stem cell fractions promote local tissue remodeling, the lack of phase III randomized controlled trials combined with unregulated offshore manufacturing transforms these interventions into an unpredictable safety hazard. Bypassing established medical safety controls introduces a high risk of catastrophic, life-threatening clinical complications.