Reminds me of when Im watching the Resident on Netflix. Most of the time when someone goes into the ER for a minor problem, they find out they have major problems. Some even die. Old saying if you don’t want to get sick, stay out of hospitals.
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This almost never happens in real life.
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A recent interview with Dr. Jordan Shlain:
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Or eat less and save the metabolic damage.
Some exercise is good, too much is bad. Exercising to burn calories is not the right move imo.
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Almost nobody exercises too much.
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Of all the risk factors for hastening death, that is the one I worry least about.
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Is there much point in eating more just to need to exercise more to burn it off?
Exercise for cardio fitness or muscle strength is different.
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Well again, who does that? A very small minority of people not worth talking about.
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A lot of people, consciously or unconsciously. I work with a guy who exercises specifically to justify eating more.
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Hahaha…with more muscle mass…I need more calories it seems… and rapamycin has me pretty shredded. So, I eat constantly… guilt and fat free. If there is food available…I eat it. S
I am staying at 188 to 190 pounds for some time. I weigh myself before hopping in the shower each morning.
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That’s cool. How long on rapamycin before you started seeing these benefits?
When I take a 1 week break I tend to feel really good the first 1-4 days after dosing, unless I get a mouth sore which kinda ruins it. I’m hoping to get to once a week dosing once I find away around mouth sores which I think is related to taking too many CYP3A4 inhibiting supplements. I’m looking to replace berberine with metformin SR and occasional acarbose, and citrus bergamot with ezetimibe and either bempedoic acid or pravastatin.
For me tirzepatide and TRT seem to give similar results. TRT alone was great for improving mood and energy but when I threw tirzepatide on top of that I just had this switch in my mind and I eat to live instead of live to eat about 95% of the time. I can enjoy simple meals without feeling like I require novelty.
Before tirz I required a lot more conscious discipline. GLP1 agonism is like willpower in a drug.
I see you take acarbose. I’m thinking of including this in my regimen when I consume starchy meals. Is that how you use it?
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Yes… using acarbose mainly for carbs. When full meat… protein…I skip.
As to shredding. For me, fat was being used as fuel started at the end of 3 months… about day 90 of dosing.
My weight was close to 200 pounds…I lost a pound… then a few more days another and by 2 months had lost about 20 lbs. Taking my weight to 180 pounds.
No loss of muscle in the process. Once visceral fat was gone.(proven by a DEXA body fat scan) weight loss stopped.
Maintaining all the good stuff… muscle mass and bone density and health. That was 4 years ago… as an early adopter of rapamycin.
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Did it happen because of Rapamycin? What was the dose?
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Yes… was the rapamycin. Dose 6 mg weekly. No GFJ.
I had lost as much as I could… and was maintaining the same weight and body mass size for 2 years. The fat I mostly lost was undetectable visually. It was my visceral fat around my organs. Once it vanished, I was still the same mass only suddenly abs appeared and cut adonis belt lines. And, still have abs and belt 4 years later… but I don’t do ab exercises like sit-ups or crunches.
I guess, if I did those kinds of exercises I would be even more chiseled
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Visceral is the worst fat of all.
It sounds like an experiment is in order.
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Stupid question alert:
Is there any way to lose visceral fat aside from losing weight? I still have some, but at the moment, I have no more weight to lose
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Agetron said he experienced visceral fat loss from rapamycin and acarbose. I’m pretty sure I’ve experienced this with tirzepatide (haven’t done DEXA scan but my stomach is flatter), I think the GIP agonist part of it directly burns fat including visceral fat.
I’d be curious what other methods people have, as visceral fat is so important to cut back on.
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Sorry for not being clear-er… the lost weight I had was the visceral fat. My size and muscles remained the same… so the lost weight was adipose tissue… definitely not needed weight. Lol.
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Ha! You were plenty clear, I did understand and realize you are a lucky genetic freak 
I’d hate you if you were not so like-able
@AustraliaLongevity sounds like gip can help me lose visceral… I do take that on occasion, but it’s not too often as my weight is bordering on too low these days. I will try to increase the frequently and just eat through it so I can maintain my weight and hopefully lose more of my visceral fat. I already take rapa and acarbose.
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You will have more success on viscral fat with a glp1 medicine that also targets glucagon: retatrutide, mazdutide, survodutide. These provide excellent reduction of liver fat: over 50% at higher doses for mazdutide:
The numbers for retatrutide are even more effective.
Tesamorelin is another option. It is really effective at reducing abdominal fat, it is prescribed to AIDS patients that suffer from HIV-associated lipodystrophy. Tesamorelin will not induce appreciable weight loss.
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