When I first cam to Hong Kong, I towered over the local populace. In a crowd I was literally a head taller than everyone else. It was great for watching shows and fireworks as I always had an unobstructed view. Nowadays, the 20 somethings are taller than me, so it’ll be interesting to see how that impacts longevity.
Unfortunately, I probably won’t live to see the results. 
Or they may have been calorie restricted in youth that kept mTOR down
Blue Zones may be an artifice of poor record keeping… which makes some people’s official age older than true…
So… ApoB is a risk factor for CVDz… level of Lp(a) is a risk factor for CVDz.
Why do so many studies fail to document levels of Lp(a) when presenting their results.
This failure likely makes interpretation of results less meaningful
Found this paper interesting, conclusions;
In future research, the mechanisms of endothelial dysfunction caused by dyslipidemia should be investigated through a detailed analysis of the interactions between endothelial cells and lipid metabolism. Second, various drugs such as statins and fibrates are used to treat dyslipidemia, but these drugs also have effects on endothelial function. In the future, the development of therapeutic agents specifically for endothelial dysfunction caused by dyslipidemia is required.
I had no idea that I had serious atherosclerosis before I had a heart attack. None of the common risk factors like smoking or obesity, golden lipid numbers. In retrospect I think the stress of divorce probably had a considerable effect, though I didn’t think about it at the time.
What were your lipid numbers for the decade prior to the heart attack?
https://x.com/TSohajda/status/1876860979897581839
@A_User: thoughts on a this to reverse plaque and solve CVD forever?
Nothing that ever made the doctor say “you’ve got a problem” or recommend a statin or any other kind of medication. Total cholesterol under 190, etc.
Prevention is guaranteed from therapies available today. Just inhibit HMGCR, NPC1L1, PCKS9, or CETP.
CVD will be solved forever with a vaccine of one or two targets above.
Other then that…
Nothing ever happens in pharma?
Thanks for your useless answer. What about my question: are cyclodextrins good?
This has been posted before:
He says their new drug is 1000 times more powerful than cyclodextrin and safe this is key. The old cyclodextrins which I believe are able to remove cholesterol crystals and convert foam cells back into macrophages, also can remove essential cholesterol from the cilia in the ear and make you go deaf. It takes continuous use, but some of us need continual use.
The old cyclodextrins are also either with IV or enema type, both of which are a pain. Maybe these could be just an injection? And if they remove only the oxidized form and are indeed safe, then IMO this is a game changer. It remains to be seen whether we can afford them of course. Also I like to wait a while and see how it goes.
How do we know if we have a problem and need this type thing? I thought cleerly was a good answer then found out it is out of pocket $1400 and insurance covers the angiogram if your Doc orders it. Of course mine will, but it turns out not to be a completely safe thing. They put a probe up your femoral artery and inject contrast. Mail the disk to Cleerly and they use AI to say how bad it is. They talk to you over your computer for 2 hours about it. So expensive and not completely safe. Stress echo is safer. Still the decision is too expensive for the average guy who doesn’t even visit the doc and can’t afford to fix the transmission in his car, much less test for something $1400 where the odds of it being bad are probably 1/50.
So if the shot is cheap and it’s actually cheap to make then we could treat based on CAC, or just take it if it’s safe. No downside. I wanted to buy shares in this company a couple years ago but they’re private.
Cyclodextrins were good and now they’re getting MUCH better.
I guess RapAdmin wanted to know your actual numbers over time until your heart attack. I’m also curious. Many people here think that the cumulative LDL/apoB exposure matters. Doctors indeed only raise the alarm when it’s already too late.
Total cholesterol was pretty consistent in the years before the heart attack - 179, 163, 163, 184, 188, 191, 185
Thanks a lot. And have you ever tested LDL or apoB? Total cholesterol is not very useful.
Did you have Lp(a) measured ?
Before my heart attack they were only doing the standard lipid panel, which I don’t think includes apoB.
LDL was 103, 65, 78, 65, 83, 91, 87
I wouldn’t be surprised if you’re Lp(a) positive with those numbers. “Good” by conventional standards, but not sufficient over long time periods, especially with high Lp(a)
Related, where was your blockage that caused the heart attack?
High Lp(a) tends to be associated with aortic valve stenosis:
Per the attached reference:
ApoB considerably underestimates risk in individuals with high Lp(a) levels. The association between apoB and incident CHD is diminished or even lost. These phenomena can be overcome and explained by risk-weighted apoB.
Lipoprotein(a) and risk-weighted apolipoprotein B: a novel metric for atherogenic risk - PMC
