I’m relieved (thrilled really) to find a local cardiologist/lipidologist well versed in research/protocols of Sniderman and Dayspring. My LDL is high and evidence of atherosclerosis is present although age-related risk factor is very low. He has me starting on 5mg Crestor. Follow-up testing in 6wks.
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Centenarians frequently display improved [i] glucose management and insulin signaling, as well as [ii] a more favorable plasma lipid and lipoprotein profile. They also show fewer overall signs of oxidative stress compared to aged controls [173, 174]. While a significant proportion of centenarians with diabetes also have hypertension, they tend to experience fewer diabetes-related complications, such as lower prevalence rates of peripheral arterial disease, neuropathy, and congestive heart failure [175]. Additionally, this population maintains relatively high cognitive function and physical fitness and is highly resistant to diseases, such as stroke, metabolic syndrome, and CVDs. This suggests that various factors may play a role in preventing or mitigating these adverse outcomes among centenarians. Here, it seems that the combination of a reduced production of pro-inflammatory cytokines regulated by polymorphisms in specific genes and an increase in antioxidants has a positive effect on their health status. The delay in age-induced vascular impairments observed in centenarians has been linked to improved lifestyle conditions, with healthy dietary patterns and regular physical activity. Given that dietary patterns profoundly influence the composition of gut microbiota, it can be postulated that these changes may also, at least in part, help attenuate low-grade inflammation, thereby reducing the subsequent risk of CVDs.
Centenarians—the way to healthy vascular ageing and longevity: a review from VascAgeNet
Open Access Paper:
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