Young adults have a cardiac epidemic. I could see this in my classmate who passed away from a coronary last month at 51.
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Indeed, My 52 y/o SIL had a MI at work and collapsed this spring. Fortunately her job site had a paramedic and nurse on staff who resuscitated her and called EMS. They wheeled her directly into the cath lab and she survived. She wasn’t feeling well that morning and almost called in sick. If she had stayed home where she would have been alone she probably would not be alive today. It was quite sobering for me.
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Wow that website is cancerous. So many ads it even tried to get past adblocking, and it tried to autoplay a video, and popped up some weird errors. Thus I couldn’t actually read the article.
That said;
My next door neighbour died of an MI during his sleep, aged 42. This was maybe 15 years ago. Never saw his 2 kids grow up.
My colleague, aged 41, did a routine screening and just found he has a calcium score of 300+
Heart disease kills more people than every single cancer combined, yet people aren’t sufficiently scared by it. There’s little reason overall to believe that millennials or Gen Z would be that much better off than our predecessors. We have significantly reduced smoking, which is great, but I’d argue that we also have incredible stress than ever, and probably worse diets (reliance on ultra-processed food etc). We certainly have worse metabolic health, and things like silent hypertension still exist. The new thing now is HFpEF which might one day rival heart attacks as the main cause of death.
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I think this is because in fact people are not born with exactly the same biological age (measured by average mitochondrial efficiency). Hence although people progress through development
A) they do it at different speeds
B) those with the older initial biological ages suffer from the diseases of aging at a faster rate.
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This is also I think a bit more dangerous in that a COVID infection damages mitochondria and hence increases biological age … and it hits fertility.
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Is this something we can prevent?
The mortality is 15% at 1 year and 75% 5-10 years after a hospitalization for heart failure
As of 2025, no medical treatment has been proven to reduce mortality in HFpEF, however some medications have been shown to improve mortality in a subset of patients (such as those with HFpEF and obesity). Other medications have been shown to reduce hospitalizations due to HFpEF and improve symptoms.
Does wild type ATTR accumulation play any role?
From wikipedia
Those with HFpEF have a higher prevalence of obesity, type 2 diabetes, hypertension, atrial fibrillation and chronic kidney disease than those with heart failure with reduced ejection fraction.[2]
Diseases of aging
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Yes it is. So I know one of the world-leading clinican-researchers in HFpEF. To put it simply, it is a disease of the cardiac tissue stemming from two things: metabolic stress and mechanical stress. In other words, glucose dysregulation and hypertension. It’s a two-hit model.
Manage those two and you likely won’t have to worry about HFpEF. And luckily, they are pretty easy for people like to us to keep under control. For the general population though, with insulin resistance and hypertension being very common, HFpEF is going to be massive in 10 years.
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Covid vax side effects?
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Theree are some encouraging results from using semaglutide to improve symptoms and enable favorable cardiac remodeling in HFpEF patients.
https://www.sciencedirect.com/science/article/pii/S0735109724081920
And
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067505
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