Frailty, Not Age, Drives Risks With SGLT2, GLP-1 Drugs in Older Adults
Cardiometabolic drugs such as SGLT2 inhibitors and GLP-1 receptor agonists offer substantial benefits for older adults, but clinicians should base prescribing decisions on a patient’s frailty and comorbidities rather than age alone, experts said at the American Geriatrics Society (AGS) 2026 Annual Scientific Meeting.
SGLT2 inhibitors are linked to side effects such as genital infections, dehydration, and dizziness, which may increase the risk for falls in older adults. GLP-1 drugs often cause nausea and weight loss, which may be harmful in patients already at risk for frailty or muscle loss.
“The key thing is that risk is vulnerability dependent, not age dependent,” said Chintan Dave, PhD, associate professor of pharmacy and epidemiology at Rutgers University School of Public Health in New Brunswick, New Jersey.
Rats, that’s why the title didn’t come up in search. That was before I joined the site in August of that year. I should have known, no way would you miss an RCT involving dapa and dementia. The study is small, and short duration, but still somewhat interesting.
Just want to confirm that I was able to get a 3 month supply of Dapagliflozin, 10mg for a total of $30 with express shipping. Would have been $15 with regular shipping.
For those who take resistance training seriously: how have SGLT2 inhibitors affected your progress in muscle strength and hypertrophy? Are you doing anything specific to minimize potential negative effects besides the basics like maintaining high protein intake and training regularly?
I have hard time understanding this study (I’m sure I’m missing something). Why would placebo group have a 65% increase in telomere, that is huge? and how was it measured? I’m assuming it was a before and after measurement, or probably it was compared to a controlled group of random (other) people?
I mean what the heck if placebo gives an increase of 65% might as well take the placebo? Unless I’m missing something, this is very weird. I mean I’ve seen placebo have say an effect of 10% on other studies but 65% is HUGE. As it stands right now, I have zero confidence in this study. You don’t just feed people corn starch/placebo and all of the sudden their telomeres lengthen by 65%.
I switched from metformin to an slgt2. I am a 53 year old male and I noticed no difference in strength or muscle size. That said, I am much more veiny. Keeping fat off always take work but it is less work with an slgt2. I get lots of compliments on my low body fat percentage at the gym and in public.
