That’s really thorough guide, very appreciate your work
Yes I’ve tried extended metformin, and it has less side effect.
But I exercise everyday, I don’t want to inhibit mTor all the day. Extended form may limit exercise benefit
So I use immediate-release form before bed, then exercise in the afternoon, hoping metformin not interfering exercise too much
ITP result of Metformin is a bit disappointing. I am waiting for TAME trial
Before a more conclusive result of whether Metformin can extend lifespan of human, I may still use Met, but in low dose
Hence the ITP result of Canagliflozin is exciting
This article suggests Metformin + Canagliflozin may be an option to try
Thanks for sharing your experience in IndiaMart, that’s really help
Following your guide, I will buy 240 tablets from this reseller ( Invokana Canagliflozin 300mg $0.63 per tablet), and to see if the drug is true. Then alternate other reseller next time
For the urinary tract infections risk of Cana, I will take probiotic and D-mannose to reduce infection likelihood
I choose these two probiotic brands (Based on the Labdoor ranking Labdoor - Best Probiotics Supplements, and price consideration)
Schiff Digestive Advantage Daily Probiotic
Garden of Life Primal Defense Ultra Probiotic Formula
(If you have other good probiotic to recommend, please let us know)
This Forum is a gem!
Really appreciate your work again