Can you share your Longevity / HealthSpan Regime?

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#326

I would substitute a handful of dried goji berries for the lutein+Zeaxanthin. Read a study that those supps are not absorbed, but the goji berries are. They’re cheaper too.

Increase D, but truly you should be tested and make it around 50. Use the mk4 form of vitamin k2, it’s the one your body (and all animals) convert to because it’s the one we use (mostly).

I think using larger and larger doses of Niacin IR is better for you and way cheaper than NMN.

Aged cheddar is much better tasting and better for you and it’s cheaper than Spermadine. Spermadine does a great job of making your gut less leaky. It increases the proteins that make the junctions tight.

Sorry I didn’t follow your instructions. I suppose if I’m going to criticize everybody’s regimen I should put mine in some day. Maybe after the crops are all in.

I should have said great job, it’s actually good.

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#327

You do know that rapamycin was secreted by a bacterium to ward off its bacteria and fungal rivals.

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#328

Your advice is exactly what I am looking for! Thank you so much! No one has a perfect supplement stack so I am always trying to improve upon it. The more input the better!!!

#329

Personally, I am in favor of the Pesco-vegetarian diet as is my father. I eat meat because I am not that against it. I do avoid hot dogs, sausages, bacon, and other highly processed foods as much as possible. I am trying to eat more vegetables like broccoli and cauliflower. I think that I won’t really go wrong with this kind of diet.

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#330

There is quite a bit of evidence that sarcopenia arises because some satellite cells either don’t produce the right proteins or are otherwise not differentiated. Hence the response to exercise is blunted. I think this links to SLC25A1 and NF kappa b (IL-10).

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#331

Although I agree that Exercise trumps diet, if you don’t have the right nutrients then you cannot build muscle.

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#332

This article seems to say you don’t need a lot of protein each day…

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#333

I would expect this to vary to some extent by age.

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#334

Resveratrol: yesterday watched a video on YouTube that explained that 1g could be too much and even promote cancer. Recommendation was to take it intermittently, not more than 500 mg, a few times per month.

I just watched the same video, after you linked it, and what it said is a low dose of Resveratrol may help cancer cells to live longer, while a high dose causes apoptosis which gets rid of cancer cells. My take away from it is to use high doses infrequently to clean out senescent and pre-cancer cells and low doses to keep cells healthy and repaired. Looks like I will use Resveratrol in a high dose (1 g) in tandem with Quercetin and Fisetin when I do my senescent cell removal on the first two days of each month. I don’t think I want to incorporate a low dose of Resveratrol in my daily intake.

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#335

I definitely won’t use resveratrol on a daily basis, which I did for some time. Two times a month along with Fisetin may be enough.

#336

I think it undermines the credibility of the entire community to even mention resveratrol.

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#337

Nice! Well rounded and light years ahead of most 27 y/o’s.

#338

I think you missed the point, Maveric. I think that Resveratrol may be only beneficial for obese individuals to extend lifespan (see video) or for clearing senescent cells. But right now, I think there’s not enough evidence to support the 2nd claim until we find out the Mayo Clinics results regarding Fisetin.

Probably best not to spend any money on Resveratrol. Now, the question is what to do with my leftover Resveratrol? I’ll probably just add it to my senescent protocol until I run out and won’t buy any more. Best to save my money for something better.

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#339

Great new dialogue!

I would propose that health, well being, quality of life and longevity all are results of sleep, diet, exercise and spiritual balance. After that, the addition of medications, supplements and other modalities ( sauna, float tanks, massage, hyperbaric oxygen etc.) However, there could be a disconnect on HealthSpan and Longevity forcing some to make a choice ( Hormone replacement may be one that applies)

Many of the supplements that were in vogue 10 years ago, seem to have crashed and burned after further studies and evaluation.

Subjective or personal experience should always be held with high suspicion to make blanket statements, but for me, if I feel better after trying a modality…guess what… I feel better:) It does not mean that you should try that modality, it is just an individual experience that has some value, but should not be used or trusted by all.

Supplements are placed into 3 categories for me.

  • Subjectively a measurable change is noted - example - I sleep better after melatonin
  • Objective measurable change - example - vitamin D levels connected to improved health, but no subjective change
  • No measurable subjective or objective changes, but choose to take due to research supporting it use for a desirable outcome -example - a 27 y/o taking Rapa, but has no subjective or objective changes to judge its value. This is the first one to get kicked to the curb when I am trying to decrease my volume of supplements.

I would be interested in how the community members decide what criteria they use to start a supplement, Rx and or other modality to improve their Health. Risk vs. reward? Scientific data? Cost?

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#340

What I do is I look at the research and then I experiment if something seems as if it might be useful. I keep detailed records of inputs and I do approximately weekly blood tests. Hence I change my protocol to fit in with the testing cycles. I may change more than one variable at a time, but I am to compare variations to see what the impact is.

For example I have a reasonably reliable formula to calculate how exogenous sources of vitamin D affect my serum level of vitamin D.

One problem with any exogenous input is that quantities matter. Hence at times I will vary the quantity to see if there is any noticeable impact.

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#341

Niacin may raise glucose level. Rapamycin may also raise glucose and fasting Insulin levels. Are they safe separately and ,especially in combination?

#342

I had not heard about Niacin raising glucose. I take both, usually 3-4 grams a day of Niacin and never noticed, but am also Keto so maybe that helps.

Do you have a paper for that?

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#343

Elevation of blood glucose with Niacin is one of the side effects and patients with DM are warned about it.
There are multiple studies on this subject. Keto diet will most likely prevent it. Don’t worry!

Introduction. One potentially important side effect known to occur on niacin is a rise in glucose levels in those with diabetes . 5 Findings from a post-hoc analysis of the Coronary Drug Project suggested that this effect also occurred in those without diabetes, leading to an increase in the risk of developing diabetes.

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#344

I believe that supplementing with vitamin C also raises glucose.

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#345

My protocol w/observations:

The problem with supplements is that there are 2 big issue:

  1. Does it really work
  2. Does the unregulated supplement I’m taking actually contain what I think it contains and, also important, does it contain contaminants and other things that may have deleterious effects?

Even if we get #1 right, #2 can fail us badly.

I’ve taken a lot of stuff, but my above evaluation has had me whittle it down quite a bit. The unregulated supplement industry isn’t exactly bathed in glory. Granted, neither is the FDA (especially after the past 2 years driving home their incompetence paired with conflicts of interest)…

I take Magnesium glycinate because that one seems a no-brainer. Dr. Best’s horse pills are a lot cheaper than Pure Encapsulates, which I have more confidence in- I mix them as a compromise.

I take K2 and D3 and Zinc, also in the, probably, no-brainer category

I restarted Glucosamine and Chondroitin after not taking it for over a decade- a bit of a hail mary for my joints which are a problem with getting my resistance training in. After 3 months, there seems to be some improvement. A totally unexpected and welcome side effect- I get up to pee less at night. It was a brutal 3-4x/night and soon after starting to take G&C, it went down to usually only once, sometimes twice. It was the only change in my protocol, so I googled and was surprised to learn that there are studies on chondroitin helping with nighttime urinary frequency. Keep expecting to revert back to 3-4x/night, but haven’t. Amazing (knocks wood).

I put Vital Proteins collagen in my Matcha Green Tea- it’s protein and I figure it can’t hurt. Of course, I heard recently that Vital Proteins uses the worst, least bio-available collagen from hoofs, whereas bones sources are much better. True? idk… but yet another ??? regarding supplements.

Finasteride 1.25mg 3 days on/1 off cycle for hair with the side benefit of prostate

Loniten: Still not sure on dosing, as I’m still applying minoxidil 1x/day to MPB area and my “beard” area in a last ditch effort to grow a beard before I die (it’s failing miserably, thus far, but Loniten is a new add, so, here’s hoping). The recent data that Loniten is cardio-protective makes the switch to oral kinda a no-brainer as long as my heart doesn’t race. It’s also a hell of a lot easier.

On hair… still debating Agetron’s formulation. If the oral proves tolerable and I completely kick the topical to the curb after my beard fantasy fails, it’ll be tough to take on the burden of a topical again unless that thread (and the gray hair thread) starts to to produce measurable results from the early adopters…

Cialis: 5mg EOD. Assuming/hoping it works the same as the more studied Viagra for both brain and cardiovascular health. I tried Viagra twice recreationally when I was younger and, even at a low dose, it made my heart scary-level race, gave me a massive headache and turned my face so red that I looked (and felt) like a stroke was imminent (not the mood setter I had in mind!). I hope the cialis has the same protective benefits because Viagra is a no- I’m literally afraid of it!

I am going to move to an alternating combination of Rapamycin and Everolimus as discussed in another thread. Been waiting for Zydus to come back in stock before doing a big order, but running out of time, so may need to get Biocon to fill the void. I haven’t decided on dosage/exact schedule for this combo yet.

In said order, I am also going to get Acarbose and Empagliflozin. I’ve taken Metformin in the past but seems Acarbose is definitely superior- just wary of the sides being too much of a quality of life disqualifier. If I was living in Asia full time, it seems an easier do on a diet where rice is central (I tried keto 20 years ago- easy to start but miserable to maintain for me). But I’m going to give it a try.

I’m also going to get Nizoral to that I can combine fasting with my Rapa/Evero dose. It seems intuitive to take the dose while already fasted, so the Nizoral gives me the bioavailability bump without GFJ or a fatty meal.

I eat 18/6- 20/4 >95% of the time for health benefits, not weight loss. Ideally I’d eat early, but that’s not practical while maintaining any sort of social life- so it’s evening, which isn’t ideal (jury is still out, but, intuitively, eating close to bed has me digesting food while sleeping, which isn’t good). It’s very easy for me to do IF after many years. I may change this to 5 days a week in case this is causing stress and to make it easier to take in more protein on heavier training days if/when my joints allow. Right now, when I do eat like normal people, my body isn’t thrilled. As I’ve opined before- humans didn’t catch food multiple times per day, and didn’t have Costco and a fridge. I believe intermittent fasting is how we were wired and current “normal” feeding, isn’t.

I also dry fast. Ideally, 5-7 days 3-4x/year. Dry fasting, from my research is superior to water fasting and doesn’t have the electrolyte issues. I do keto the day before to speed ketosis/autophagy. I’ve only done 5 days so far, but really want to do 7 and, eventually do a 10 day once/year. It’s more difficult than a water fast- day 2 and 3 suck. It limits activity and, like all fasts, it doesn’t end with the fast; as the re-feed is as important as the fast.

I used to take fish oil and believe it’s important. I just never know if the supplement that’s been in hot warehouses and trucks is rancid already when I get it. Again, the very real problem of unregulated crap shoot supplements.

Truth be told, I still eat way too much junk- still waiting for that peer reviewed study showing Haagen Dazs is superior to rapamycin, and is the true elixir of youth…

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