Can synergizing rapamycin + metformin together cause mTORC2 inhibition at lower doses of rapamycin than would otherwise happen?

#1

Is there any “additive” effect to both inhibiting mTORC in different ways?

#2

I’ve seen no research on this issue - so I suspect the answer, like in so many areas of rapamycin / and metformin, is “we don’t know”.

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#3

I don’t think there is an additive effect such as taking sirolimus with grapefruit juice, which boosts rapamycin in the blood by 300%. However, Blagoskinny says they are synergistic in that they can cancel each other’s side effects.

See

https://www.nature.com/articles/cddis2014520#ref-CR165

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#4

Is anyone taking rapamycin, statins and drinking grapefruit juice?
I know that certain statins and grapefruit juice taken together is not advised. Crestor is ok but not Lipitor or Zocor.

Thoughts?

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