It’s a huge concern for me.
This is based on research in worms.
We did only one properly controlled study of statins and IgG glycosylation and found that Rosuvastatin does not affect the IgG glycome (or GlycanAge).
https://www.sciencedirect.com/science/article/abs/pii/S0304416517300831
In cross sectional studies statin use will often correlate with increased glycan age, but this is confounded with underlying medical condition why statins were prescribed…
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If you place GlycanAge results over cholesterol control, you are not going to live as long as you hope.
Instead of statins use Bempedoic Acid and Ezetemibe. Sorted.
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@Gordan_Lauc Thanks so much for joining the Rapamycin News Forum! Tremendous interest here in all of the BioAge clocks and their evolution. We particularly need better measures of success for rapamycin and the other longevity interventions. Any insight you could provide on rapamycin use and GlycanAge test results would be greatly appreciated. Welcome!
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As an early adopter of rapamycin weekly. I have been testing regularly with GlycanAge past 3 years.
My most recent results.
Chronological age 66 years… glycan biological age is 44 years. A 22 years difference.
I am told by Gordan Lauc’ s research staff Dr. Alex Vojta that my results are a fraction… of a fraction of others tested. Very unique results on rapamycin.
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Previous GlycanAge results. A 15 year increase in aging happen when I drastically increased my rapamycin for 7 months. I was taking 8mg and GFJ… 53 ng/mL after 2 hours. Believing Mikhail Blagosklonny… I was doing more rapamycin thinking it was better. It obviously was not. Ouch!
My results reduced (see below) when I returned to a lower weekly dose 6 mg weekly.
I have now reduce my dose to 4 mg, weekly and will retest in six months.
Here is my GlycanAge test history, showing a spike… November 2022 after high rapamycin dosing… and the gradual decline, going back to a more modest dosage of 6 mg per week.
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I just watched this excellent presentation from June 17th, 2024.
Prof Gordan Lauc: Glycan biomarkers for personalized preventive healthcare
https://www.youtube.com/watch?v=_LrS9my_ioQ
Mention of some interventions - metformin, SGLT2i, GLP 1, exosomes, but nothing on rapamycin.
@Agetron besides your overall positive results on rapamycin - and the negative for the higher dose, have your GlycanAge Tests given you any other longevity insights into interventions? It looks like what you are doing works, but is there anything else that didn’t? Did you feel any different when your GlycanAge went up? (on the higher dose)
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Glycans are giving you an indication of your inflammation status throughout your body.
Senescent cell activity is tamped… your inflammation is low when your glycans are stable. You’re not going to have issues of arthritis or pain which come with inflammation.
Except for slight swelling in face and ankles, there wasn’t really a lot of side effects that health was going wrong. It was more like silent pathology, so all seemed well… when it wasn’t.
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