Can ROCK inhibitors be pro-longevity?

eg (DOC) Can a combination of senolytics with ROCK inhibitors and 5-LOX inhibitors contribute to tissue rejuvenation? | Dmitry Dzhagarov - Academia.edu

Perhaps something to track over time:

ROCK inhibitors have potential therapeutic applicability in a wide variety of pathological conditions including asthma, cancer, erectile dysfunction, glaucoma, insulin resistance, kidney failure, neuronal degeneration, and osteoporosis.

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00683

I’ve been interested in this topic for a while. Statins are Rho-kinase inhibitors (one type more than the other, as research points out). It has been suggested in quite some studies that these suppressive effects on Rho kinase signalling of statins, may be underlying many of their pleiotropic effects.

ROCK inhibition may explain the benefits of Reishi mushrooms.

With regard to “clinical applications for anti-erectile dysfunction”, ROCK inhibition seems to be the mechanism of action of Tongkat Ali, the Malaysian natural Viagra.

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