This seems to be the only study that describes the effect of omega-3 on rapa exposure, but the reason is not due to high fat, rather because omega-3 can inhibit CYP3A4. The conclusion of the study is that the rapa dose should be reduced by 25% when taking omega-3 at the same time.
So If this is true, can I reduce the 6mg/week to 5mg when I take rapa with omega-3 together? Actually I ‘d like to reduce the possible side effects by lowering the rapa dose 
( I take omega-3 fish oil 2g Include EPA 1000mg&DHA 500mg every day ) .
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You probably can, and assume you’re getting the effective 6mg/dose per week, and if that relieves some unpleasant side effects that is all the more reason.
But we really know so little about what the optimal dose is for humans for longevity that any dose we take is pretty speculative in terms of the best outcome. So, yes, you can do it, but we don’t know if 5, 6, 7, 8… 10mg /week or higher is optimal for any one person.
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Assuming the effect of omega-3 is indeed to inhibit CYP3A4, then timing issues also come into play if you want to lower the rapa dose. When taking GFJ, or grapefruit itself, they time their rapa around that to get the actual effect. I don’t know how fast omega-3 acts to inhibit CYP3A4, and if any concomitant food intake impacts that timing. Safest way to know is to actually measure blood levels of rapamycin to see the effects, but that may present practical challenges. Without measuring, how do you know what this intervention does - it’s hard to establish dosing just relying on that paper.
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