Just consuming all calories in a 2hr window vs across the day in CR mice, further increased lifespan by 10% (959 vs 875)
Full on 30% CR + 2 hr TRF = 21% lifespan extension. Who needs Rapamycin?
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More new research on caloric restriction:
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Caloric restriction (CR) extends organismal lifespan and health span by improving glucose homeostasis mechanisms. How CR affects organellar structure and function of pancreatic beta cells over the lifetime of the animal remains unknown. Here, we used single nucleus transcriptomics to show that CR increases the expression of genes for beta cell identity, protein processing, and organelle homeostasis. Gene regulatory network analysis link this transcriptional phenotype to transcription factors involved in beta cell identity (Mafa) and homeostasis (Atf6). Imaging metabolomics further demonstrates that CR beta cells are more energetically competent. In fact, high-resolution light and electron microscopy indicates that CR reduces beta cell mitophagy and increases mitochondria mass, increasing mitochondrial ATP generation. Finally, we show that long-term CR delays the onset of beta cell aging and senescence to promote longevity by reducing beta cell turnover. Therefore, CR could be a feasible approach to preserve compromised beta cells during aging and diabetes.
Cristiane dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin W Hetzer, Mark H Ellisman and Rafael Arrojo e Drigo
bioRxiv. posted 24 August 2023, 10.1101/2023.08.23.554369
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Based on the latest Mat Kaberlein paper, it appears that CR is more of a normalizer of lifespans for shorter-lived species of mice (extends their lifespans more) and doesn’t extend lifespans of long-lived strains as much.
Another reason that CR may not be as beneficial as once thought.
Can you share a link?
Ok, think it might be this one?
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Yes, that is the right one. 
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I have also heard MK say CR reduces lifespan in some mouse models so he concludes CR is not a panacea
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There seems to be evidence in humans, not for maximal lifespan, but for reduction in mortality. Subjects were not followed to death, so we do not know at what age they died.
Calorie restriction without malnutrition in World War I and II
Involuntary episodes of CR are not uncommon in human history, but only few of these events were not accompanied by malnutrition, because the local governments wisely enforced food restriction with an adequate consumption of essential nutrient-dense foods. During World War 1 in 1917, Danish men and women were forced to reduce food consumption for 2 years, but with a well-planned and adequate consumption of whole grain cereals, vegetables, and milk. The result of this undesired experiment was an impressive 34% reduction in death rates (Hindhede, 1920). Similarly, in Norway during World War 2, the citizens of Oslo underwent a forced 20% CR without malnutrition (i.e. Norwegians were provided with adequate intake of fresh vegetables, potatoes, fish and whole cereals) for approximately 4 years (1941–45). In this forced experiment, mortality dropped by 30% compared to the pre-war level in both men and women (Strom and Jensen, 1951).
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Of course, CR can help you hit 120. It just won’t take you to 130. (According to the paper).
Rapamycin, Rapamycin combos and telomerase activators technically could take you there.
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