@DrFraser I get the feeling that you are discussing classic, “full blown”, 25-30% CR? I agree with you on huger, psychological cost, etc for that.
What are your thoughts on mild CR though? Perhaps of a similar magnitude to what people actually ended up doing in the Yale run, NIH funded human clinical trial with results published in multiple Nature journals?
That seems to be similar to the degree of CR that is part of Bryan Johnson’s and Mike Lustgarten’s diets and neither of them seem to be under muscled.
See for example the papers on this chain: