A few years ago, I loaded up on rapamycin, which I have been keeping in the freezer. It was a big supply and lasted till recently. Ran out, took a six month break and ordered again from the same source as before - Pravin Lahoti at Varun Medicals. I originally ordered from him in 2021 after looking around online for licenses, length of time in business and other things I hoped would indicate legitimacy. He came through then and now.
36 boxes of Zydus Siromus for $216 ($6 per box), $45 shipping, and ~$10 bank wire fee, for ~$275 total (~$1.27 per pill, all in). The pills were fresh, with an August, 2027 expiration date. Delivery was about two weeks from the day I contacted him. He mentioned that he also takes Wise and a couple of other services. I prefer bank wire because it’s an established, trouble free method.
I have ordered a number of medications from PM Business Hub in India and dealt with Vidhan. His customer service and response to texts if almost alway immediate. He texts you updates on the shipping process frequently. Shipping time has been one week to two weeks max. I recommend him. His info:
Anyone is hoarding any medication for the impending trade war with China? I have not bought anyting from India so all my medications are from here but I am starting to worry as China does have a huge market share in basic medical ingredients.
As of tomorrow, all mails are stopped from Hong Kong to US.
Good news Jagdish replied with the shipping label. This is in line with someones comment that it can take over a week for Jagdish to fetch drugs and get shipped. I guess a new threshold of giving him 2 weeks post wired funds arrive to get back.
Gotta wonder what mess tariffs and drug import customs are doing to these businesses… ;(
This is an excellent point!!! I feel China has all the power and I don’t foresee them crying uncle first.
Does anyone here know which common drugs are vulnerable or how we find out? It might be a great time to place a bulk Good RX order outside of insurance (at least for me who has useless insurance).
I imagine no one knows, but I’ll just list my US sourced rx’s on the chance anyone knows
Estrogen gel, progesterone, repatha, colchicine, acarbose, generic synthroid, cytomel
Also, does anyone know the expiration date of these items… meaning, I assume I can safely buy 12 months worth?
I placed an order with Jagdish about 2-3 weeks ago for Sirolimus and just received it. Everything in order, and he responded promptly. I wonder if he is maybe sick now or something?
I made the mistake of breaking empagliflozin in half- destroys the slow release enteric coating and I received huge hit of the drug that just flattened me. Took me a week to read the drug insert-so stupid. Double ck dapa. High peak flozins can induce AKI
I’m not sure that empagliflozin can’t be pill-split. We’ve got some indications that it can be (but ideally if people used a CGM and could confirm or deny this, I’d be greatly appreciative).
See:
Background:
Costs are important cause of therapeutic noncompliance in type-2 diabetes mellitus (T2DM). Half-tablet empagliflozin (EMPA)-25 mg has lowest monthly cost among all EMPA preparations; data is unavailable on efficacy of half EMPA-25. This study compared real world weight loss and glycaemic outcomes of 10 mg versus 12.5 mg versus 25 mg of EMPA.
Methods:
Data, retrospectively captured from records of 2 different centresfor patients > 35 years-age having T2DM on EMPA as part of standard pharmacotherapy for T2DM, having > 6 months follow-up data available was analysed. Patients were in 3-groups depending on EMPA dosage: Group 1 on EMPA 10 mg/day (1-tablet EMPA-10), Group-2 on EMPA 12.5 mg/day (half-tablet EMPA-25), and Group 3 on EMPA 25 mg/day (1-tablet EMPA-25). Primary endpoints were glycaemic efficacy and weight-loss.
Results:
Of 3601 records screened, data from 599 patients (184, 239 and 176 in Group-1, 2 and 3 respectively) was analysed. All 3 groups were comparable with regards to sex, blood pressure, haemoglobin, renal function, medications use. Group-3 were significantly older, had longest diabetes duration, highest HbA1c and lowest body mass index. Glycaemic efficacy was comparable among groups (ΔHbA1c Groups 1-3: −0.9 (−1.9 – 0.0), −1.0 (−1.8 – 0.5) and − 1.0 (−1.5 – 0.22], respectively; P = 0.363). Patients on EMPA 12.5 or 25 mg/d had significantly higher total (−1.4 [−3.0 –0.2] vs. −0.3 [−2.4 – 1.32] kg; P = 0.028) and percent weight-loss (−1.75% [−4.15 – 0.26] vs. −0.44% [−3.11 – 1.39]; P = 0.039), and significantly higherfraction achieving HbA1c < 5.7% (12% vs. 0; P = 0.021), compared to EMPA-10.
Conclusion:
Half EMPA-25 is the most cost effective way of using EMPA in clinical practice.
FWIW, I’ve been taking empagliflozin for five months now. I get the original pills, not any generic. I split 25mg pills into two roughly 12.5mg/day, and have experienced no side effects that I can tell. I’ll have the results of my blood tests sometime next week, so I’ll see if there has been any impact on biomarkers. My suspicion is that splitting pills doesn’t matter, but of course I could be wrong. I should be using a pill splitter, but I lazily use a knife, so my splits are not perfect halves most of the time, but nothing too crazy, maybe 10mg + 15mg at worst? No sides that I can detect. YMMV.
$105 for 30mg. At say typical low dose of 2mg/week thats 15 weeks for just $105. Ad in a few $$ for syringes, the dilution water (BAC water) etc. And its barely beer money / money. In fact most will spend more on beer / mo then this source for tirzepatide. Very easy to pay for unlike buying pills from India. I’m at my ideal weight and like BHRT + thyroid, GLP-1 is also a beneficial hormone to micro dose for health. I’m taking about 0.2mg/week + 0.2mg/week of retatrutide (adds GIP to the dual aganist tirzepatide) for glucagon/liver control. I split my wkly dose into 2 to micro dose / week. At my dosing my costs for Vitamin D/K2/mo (using a silly example) is more then GLP-1.
I’ve recently stocked up!!! Craziness abounds.
FWIW my most expensive suppliment / mo is probably; stemregen. 2nd probably prodrom plasmologens. Can’t report anything noticable. Its all on “faith”. ;( ;( ;( and of course the company’s research. Alex Kikel on youtube has alot to say on these compounds.