The difference with generics is absorption/bioavailability, which Pfizer’s is about 30% better. This is why generics did not get approved in EU.
2 Likes
The Pfizer version of rapamycin uses Elan’s nanocrystal technology (thus the improved bioavailability by 30%) but of course, its 10X the price of the generics (or more, in Europe). Rapamycin and NanoCrystal Formulations
I’m surprised that would be the reason for non-approval in the EU. The generics still work fine but they are just a little less bioavailable.
2 Likes
It is EMA requirement to grant marketing authorization for generics to have same bioavailability so they can replace non-generic medicines 1:1. In a way it makes sense as the dosing would need to be adjusted otherwise for patients that critically need it. For purpose of longevity experimentation this is completely irrelevant probably.
2 Likes
you ship to spain? or customs makes that impossible?
I put in a $500 order with Jagdish on December 12, and I finally received the package today, January 10. It was never opened by customs that I can see. It spent the majority of time apparently sitting in the Mumbai PO being “prepared for shipment” - at least according to the tracker data. Once it hit the states (NY Jamaica Iternational Distribution Center), it was just a few days before appearing at my door. Crazy - weeks in India, days in the US. Almost a month altogether. Go figure.
3 Likes
Pretty typical transit time in my experience
1 Like
Yes I do. You can order via the site if you wish to.
1 Like
I do not recommend The Antiaging Store. I never received the package, which was not directly their fault. But they promised to reimburse me and never did. Now They’ve stopped replying to my emails.
I had success with The Canadian Prescription Drugstore. They had a reasonable price for Dapagliflozin.
3 Likes