Possibly. Although, I’m not sure how widely known it is at the moment.
And it’s very much in a legal area I believe. I’m glad someone is doing it though.
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Yes - “gene-doping” is going to be a booming area. It will be interesting to see how the World Anti-doping Agency deals with it.
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Interesting - I’ve never heard of this “integrated Health Systems”…
What I find strange is that they have absolutely no names (i.e. professionals who have a background in gene therapies) listed on the website , in fact no names at all that I can find.
I was working with PHDs out of Stanford U. with published papers and patents. This company looks like more of some sort of vaporware site setup by who knows?
Click on “Team” for the website, and it takes you to “consultation” where they have “testimonials” with “patient 1”, “patient 2”, etc. and… no team.
Given the vagueness and lack of information on the site - I’d avoid it at all costs. Anything that doctors don’t want to put their name on is something to be afraid of.
Minicircle is more legitimate, but still on the edge: Our Therapies - Minicircle
At least with Minicircle you can research the principles of the company: About Us - Minicircle
You can search on LinkedIn and at least find a few people associated with Minicircle:
But its a little scary to me that the founder doesn’t have any academic credentials associated with science or medicine:
Walter Patterson (no academic qualifications listed)
https://www.linkedin.com/in/walter-patterson-2b7a45a4/
Mac Davis (3 years of science education -… seems like undergrad, as no indication of graduate level work)
https://www.linkedin.com/in/macdavis/
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Watched a short video by Sinclair, that talked about 5 longevity biomarkers. One of them is Albumin, 1st I heard. Is anyone tracking it as a longevity marker? How has your Albumin trended since started on Rapamycin?
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Yes - albumin is one of the standard measures in the Levine Phenotypic calculator. In my 4 years on rapamycin there has not been much change - its at 4.6 mg/DL typically.
See the old news below from Dr. Morgan Levine (creator of the Levine Phenotypic biological age calculation)… on Rapamycin’s impact on epigenetic measures of aging… I have attached the Excel Spreadsheet for doing your own Levine Phenotypic Age calculations at the bottom of this post (from Mike Lustgarten’s page) developed by Nick Engerer.
https://twitter.com/DrMorganLevine/status/1468025405877669892?s=20
3ba41-dnamphenoage_gen-1.xls (31.5 KB)
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Just did a quick check of blood panels… my albumin from 3 months before I even started rapamycin in July 2020 was at 4.1 g/dL.
Has stayed in that range past 3 years on rapamycin… checked every 3-4 months 4.1 to 4.5.
Last test in Mid-April was 4.4 g/dL so literally no change before rapamycin and after 3 years of continuous use.
Hmmm?
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The longevity papers I saw were from almost a decade ago. Have there been more support for that aspect since then? Mopst of the papers seem to be about muscle and anti-frailty.
Wonder if one way to think about this is to wait until one is old enough that one starts experiences muscle loss/weakness (but before sarcopenia).
Ie less need earlier in life and more need later in life.
Perhaps this also means that for those with some decades left until those ages, we should perhaps go more with the “Valter Longo” type of approach to protein than “Peter Attia” approach - perhaps that with these muscle therapeutics coming online we do have to overload with muscle today to avoid frailty in future decades…?
Finally, found this paper interesting - discusses how big the potential of myostatin therapies from pre-clinical models led to large clinical efforts the last two decades, but with little result. Though it does seem that the paper thinks gene therapy might have a bigger chance than more conventional medicines have shown.
So my understanding is that this company is in some way related to Liz Parish. I haven’t looked at the site for a while. I have a feeling that they may have taken some information down, probably for legal reasons. I remember a watching a few interviews with the principals a few years back.
I agree with you that it’s questionable. Again, all of these treatments exist in a grey area. I’m not sure it’s legal to offer the treatment and I seem to remember they operate outside the US. I’ll wait until it’s proven safe and effective.
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Of course… there is a book planned (by Bryan Johnson):
Millionaire Biohacker Says Algorithm Runs His Life: ‘My Mind No Longer Decides’
Bryan Johnson — who went viral for blood plasma donations and penis shockwave therapy — shares the philosophy behind Blueprint, his very expensive longevity project
Having embarked on this anti-aging odyssey two years ago, spending some $2 million per year, Johnson explains the regimen in great detail at seemingly every opportunity. As he puts it on his website, “My journey and protocol is openly shared and accessible to all.” He also has a forthcoming book, Don’t Die , about “the future of being human.” But a number of longevity experts have voiced skepticism about whether Blueprint can really turn back the clock in the way Johnson hopes, given how genetics play a role in determining lifespan and the all-consuming effort and discipline these methods require. And he has a way of talking about his “protocols” that make them sound like a historic leap forward in human consciousness — sometimes straining credulity.
From this week in The Rolling Stone: https://archive.ph/eXJbA
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I am rooting for Bryan. I hope he can make some breakthrough in longevity that can help humanity be healthier or live longer or both.
Go Bryan!
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I find his experimental approach interesting… a little scattershot, but hopefully something works well for him. I definitely hope he’s successful.
He’s really raised the attention on longevity and I think more people are interested and realizing that it getting real, and there are many things people can do today.
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I think he should be more focussed on the science (which does require debate and discussion) and less so on promoting the “blueprint” brand of substances. He would be well advised to join the rapamycin news forum and participate in the discussions.
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He is not a scientist and is not interested in scientific discussions as far as I understand from his YouTube lives every Sunday. He has a team of experts for that. He is just willing to be a lab mouse himself and totally committed to it. He is more interested in philosophical and sometimes psychosocial discussions that are not really scientific but more existential.
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I hope some good and no harm comes of it. I pay no attention to him. He is an entrepreneur to the core. He is on a money making quest, not a scientific exploration, in my judgment. I may be wrong but if I am someone here or elsewhere will alert me to the discovery. I may miss out on being on the cutting edge but I’ll save my mind for better bets.
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“Creatine is one potential myostatin inhibitor. Added to resistance training, creatine can increase the growth potential of muscles by lowering myostatin. In one study on healthy 27 men, creatine prevented increases in myostatin. Some researchers believe this may add to its muscle-building potential in power athletes”
This is something I didn’t know. I have been taking creatinine for decades because it was always touted by muscle-building articles. I put 5 - 10 grams in my coffee daily. It is probably one of the reasons that I haven’t experienced any self-detectable sarcopenia.
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It’s pretty much what I thought would happen. He’s becoming another longevity ‘guru’ selling products. That said, I don’t think this is a necessarily a bad thing. I’ve watched a lot of Bryan Johnson’s videos and I was quite harsh at first. I genuinely think he’s trying to do good. I also like the rigorous testing approach, and if I had the means, I’d be doing something similar. I still think this is all too early because we just don’t have anything proven yet that can move the needle.
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It won’t be Bryan that makes a breakthrough, he’ll just be on the receiving end of it. I seriously wish him all the luck.
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I started taking creatine about six weeks ago and I’ve already noticed an increase in my muscle mass. My weight was stubbornly stuck for a couple of years, since the creatine I’ve put on five pounds and my diet is the same.
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Creatine is still at the top of most lists, not including steroids, for muscle mass increase.
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