Hi, I’ll be taking some vaccines in the coming months. I was wondering how to prepare to improve immune response. Off the top of my head I can think of everolimus, basically rapamycin based on Mannick’s study. I also wonder if Vitamin D and Zinc, based on its role in immunity might be important. And taking the vaccine after a good night’s sleep. Thoughts about how to improve vaccine response or make the best of it?
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I take Zinc and vitamin D every other day.
This week took the flu and pneumonia shots in left arm… shingles shot in the right… would have added RSV… but needed a doctors order… that in a few days.
Three vaccines… all at once… lets do this! No side effects…took it easy the next day… slept a lot the next day. Was back to full speed two days after. No swelling at injection site… or pain (something that is typical in the past)…
Get my 2nd shingles shot in 2 months. All caught up.
Saying no to covid shot after 2 Pfizer shots and 2 boosters in the past, and had covid at time of last booster… covid was nothing… covid for me was a stuffy nose 3 days … and back to negative and full energy. Had my wife not been so ill… 10 days with covid …I wouldn’t have tested myself… felt completely normal.
I do think my immune system is a lot more robust after 3 years of rapamycin. Travel lots… not sick… and seasonal allergies gone the past two years. Use to get really bad spring and fall allergies… now nada.
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Can’t find anything that suggests Zinc would help.
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What supplements or drugs do you think help in boosting vaccine response? Is Rapa and Vitamin D in the clear?
Not sure. The Mannick study was positive for Rapa, although not sure how you would dose it in relation to the immunization. Vitamin D may help but not good data related to vaccine. A healthy person should mount a good response without having to do anything extra.
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People with low amount of influenza titers seems to have had the greatest benefit:
In a subgroup analysis, the subset of subjects with low baseline influenza
titers (≤1:40) experienced a greater RAD001-associated increase in titers
than did the entire intent-to-treat population (Fig. 1B). These data suggested
that RAD001 may have been particularly effective at enhancing the in-
fluenza vaccine response of subjects who did not have protective (>1:40)
B shows those with baseline influenza titers <1:40
Which suggest to me that people who are healthy but have not been exposed to a virus might have a greater benefit than those who already have.
I can’t really wait to get immunized (I haven’t taken rapa the last couple of weeks), but I would do the same protocol as the Mannick study and dosing. That would be 5 mg sirolimus or everolimus a week or 0.5 mg a day, for 6 weeks, then a 2 week break before immunization.
Regarding Zinc I think zinc deficiency isn’t good for the immune system, hence top it up as the risk-reward is low.
So to sum up I can’t do a rapamycin protocol right now as I can’t wait 2 months for immunization.
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This is purely anecdotal N=1 but before i get vaccinations I take cimetidine and load up on probiotics especially plantarum.
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Zinc is essential, but easy to over do.
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I exercise, especially cardio, going into and after my shots, seem to be several studies on it across different types of vaccines:
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Have also heard that you want the repeat vaccine to be in the same arm as earlier shots.
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My impression is that Zinc is an antiviral agent, not necessarily an immune booster.
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I recall from one of Kaeberlein’s interviews that elderly patients taking Rapamycin had more robust flu vaccine responses than the control group.
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