I finally got it finished. Here is the episode with @RickCohenMD on boosting Testosterone, avoiding testosterone envy, and getting higher T (if you need it) while improving your healthspan.
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Here’s a very good paper on rapamycin and testosterone (natural or TRT) from Healthspan. I have modeled my own schedule to follow this recommendation for “Thinking in Pulses: Balancing Anabolism and the Cellular Benefits of Canabalism”
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That’s interesting. I also do most of my weight lifting M-F, so I am going to make Sunday my dosing day instead of Monday.
I am wondering now about age as a reason to adjust the dose. Specifically, it would be good to know if the mTOR over activation is more of a step function (like female estrogen decline post menopause) or a drift (like male testosterone decline). If it’s a step function, then you would think anybody ~40 and up could follow the same dosing recommendation based on e.g. body weight. But if it’s a drift over time, then you’d think the proper therapeutic dose for longevity would be increasing in age.
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@Barnabas Its a good question for smarter people than me to figure out. But I think the dose goes up with age (goes down with youth). With more age I have more dysfunction and less time left to fix it.
I wonder if testing the level of ribosomal protein S6 (RPS6) phosphorylation would be a proxy useful for measuring the impact of your rapamycin dose on the type of pathway you care about for longevity.
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Great episode, thank you @Joseph_Lavelle for the insightful topic.
An interesting question for me would be how to align our strategy around the alteration between catabolic and anabolic pathways with infradian (multi-day) rhythms of our endocrine system. For instance, when looking at studies like Circatrigintan Cycle of Salivary Testosterone in Human Male:
The data showed rhythmic variations with 2 different infradian periods. The differences between extreme values of the circatrigintan (period of 30 days) and circavigintan (period of 20 days) cycles were found to be highly significant (p < 1E-9; p < 1E-8). Conclusion. We believe that this is the first study demonstrating the existence of circatrigintan and circavigintan rhythms of testosterone in human males. Our findings might have implications in human physiology and pathophysiology.
→ could it be that without alignment, you might be allocating rapamycin intake at the time of your natural TRT peak?
Could these circatrigintan cycles provide natural recommendations for timing alterations between anabolic and catabolic pathways? To which extent those cycles could be influenced by our intervention strategies?
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@SilentWatcher Thanks for the info on 20-30 day cycles. I hadn’t heard of them before. I don’t know what to make of it yet. How would you address it?
I’m also curious about this. Does it mean we should align our training with these cycles, running an anabolic pathway for 10-15 days and a catabolic pathway for the next 10-15 days?
For more context, check out this study: Does lunar cycle affect biological parameters in young healthy men?. It suggests a connection between the 20-30 day cycle (similar to TRT rhythm) and the lunar phase, showing quite significant effects on testosterone levels in men: Melatonin (MLT) and Testosterone (TST) levels were significantly lower during the full moon compared to the new moon, both in the morning and evening…
According to the study, the catabolic pathway might be more prominent around the full moon, where TRT is low. Very interesting. However, we should be cautious as this idea might veer into the mystical and speculative territory.
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