Three months ago I had my first blood work after starting rapamycin, and my cholesterol had shot WAY up.
Brought my rapa dose down from 10mg per week to 7mg per week, and added 10mg daily of Atorvastatin (Lipitor) to my stack. Had a new test yesterday and everything is looking better! Pretty amazing how much my lipid numbers changed. Here’s the before/after:
Aging.ai has me at 34, which is 12 years younger than my actual age:
I would try to get my LDL numbers even lower than that by adding ezetimibe. Below 70 is good, below 55 is great and below 40 is perfect.
Okay thank you for that advice!!
Very good. Congratulations.
What’s your source for this opinion?
Great news! I’m hoping for similar results as I have had a similar issue. It definitely seems that a higher Rapa dose leads to higher LDL in proportion to the dosage. Is there anyone who is taking a large (20 mg+ equivalent) Rapamycin dosage that could share their LDL numbers?
I am taking 20mg every 2 weeks and my blood tests on 7-24-23 (2 hours after my Rapa 20mg on empty stomach):
Apo-B : 90 mg/dL (previous value on 4-10-23 before Rapa was 78 mg/dL)
Apo-A : 150 mg/dL
oxyLDL : 124 ng/mL
Sirolimus : 75.5 ng/mL
Insulin : 3.9 uIU/mL
I have been on 10mg Lipitor for years.
I started on Pantethine 450mg 2x/day Aug 1, and will recheck Apo-B & oxyLDL on Aug 28, 7 days after the last Rapa dose on Aug 21.
Very high-risk includes documented ASCVD (any clinical CVD/event or imaging), diabetes with end-organ damage, or three major risk factors, severe chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <30), heterozygous familial hypercholesterolemia (HeFH) with ASCVD or another major risk factor, or a SCORE ≥10% (e.g., annual CV death ≥1%) in which the LDL-C target is ≥50% reduction in LDL-C with goal <55 mg/dl. High risk is a very high single risk factor (total cholesterol >310 mg/dl, LDL-C >190 mg/dl, BP 180/110 mm Hg), diabetes >10 years or with one major risk factor, moderate CKD (eGFR 30-59), or SCORE 5-9% in which target LDL-C is <70 mg/dl.
2019 ESC/EAS Guidelines for Management of Dyslipidemias - American College of Cardiology (acc.org)
Infants have levels below 40 and they don’t develop ASCVD until their early teens when LDL levels rise.