Three months ago I had my first blood work after starting rapamycin, and my cholesterol had shot WAY up.
Brought my rapa dose down from 10mg per week to 7mg per week, and added 10mg daily of Atorvastatin (Lipitor) to my stack. Had a new test yesterday and everything is looking better! Pretty amazing how much my lipid numbers changed. Here’s the before/after:
Great news! I’m hoping for similar results as I have had a similar issue. It definitely seems that a higher Rapa dose leads to higher LDL in proportion to the dosage. Is there anyone who is taking a large (20 mg+ equivalent) Rapamycin dosage that could share their LDL numbers?
Very high-risk includes documented ASCVD (any clinical CVD/event or imaging), diabetes with end-organ damage, or three major risk factors, severe chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <30), heterozygous familial hypercholesterolemia (HeFH) with ASCVD or another major risk factor, or a SCORE ≥10% (e.g., annual CV death ≥1%) in which the LDL-C target is ≥50% reduction in LDL-C with goal <55 mg/dl. High risk is a very high single risk factor (total cholesterol >310 mg/dl, LDL-C >190 mg/dl, BP 180/110 mm Hg), diabetes >10 years or with one major risk factor, moderate CKD (eGFR 30-59), or SCORE 5-9% in which target LDL-C is <70 mg/dl.