I’m still blown away by this research finding — In plain english: increasing circulation of blood in old mice led to 45% lifespan extension! 45% lifespan extension. Never heard of. Neither Rapamycin nor any other drug or supplement can match this.
How do you improve circulation in humans? Cialis and L-arginine come to mind. Plus regular walking and other daily activity. Obviously weight lifting can be make you more vascular, but that’s a double edged sword, high doses of weight lifting is associated with increased mortality.
TL;DR Make your blood go to places to live longer. Walking and/or daily increased activity is a no brainer. Cialis and/or L-arginine can be considered. More generally keep your blood vessels healthy, and super functional to get this OP longevity benefit.
A research team found that increasing VEGF (vascular endothelial growth factor) signaling in mice helped maintain better blood vessel health during aging, which significantly improved their overall health and lifespan. By boosting VEGF levels, the mice showed numerous benefits including better metabolism, stronger muscles, healthier bones, less inflammation, and fewer age-related diseases. The researchers demonstrated that naturally declining VEGF signaling in aging contributes to various aspects of aging, and that restoring youthful VEGF levels could help counteract these effects. The treatment extended the mice’s lifespans by 45% and helped them stay healthier into old age.
Mechanism: Stabilize hypoxia-inducible factors (HIF), which can upregulate VEGF under low oxygen conditions.
Notes: Approved in some regions for anemia in chronic kidney disease, and could theoretically impact VEGF.
Erythropoietin (EPO) or EPO-Stimulating Agents:
Mechanism: Increase RBC production; under hypoxic conditions, could secondarily raise HIF and VEGF levels. SGLT2-i can do that.
Notes: Used for anemia, especially in renal disease and sometimes in sports doping contexts.
Nitroglycerin (Nitrates):
Mechanism: Increases NO and enhances blood flow.
Notes: May indirectly support VEGF-related pathways, but not used clinically for that purpose.
Growth Hormone or GH Secretagogues:
Mechanism: GH can influence various growth factors and tissue repair processes.
Notes: May affect the entire growth factor milieu, including VEGF, although not a standard approach.
Experimental VEGF Gene Therapy or VEGF Protein Injections:
Mechanism: Directly introduce VEGF or its genetic material to stimulate angiogenesis.
Notes: Strictly experimental or in clinical trials for conditions like critical limb ischemia or heart disease. Not a conventional “drug” in pill form.
Conclusion:
The above lists are a starting point for exploration, not a definitive guide. Many factors influence VEGF—most interventions are not specifically designed to raise VEGF but may do so indirectly as part of improving vascular health or responding to hypoxic or ischemic conditions. For targeted VEGF modulation, medical supervision and context-specific treatments (like experimental gene therapies) are essential.
Nothing works better on increasing blood circulation than movement or exercise.
This is probably just another reason why VO2 max is such a strong predictor of longevity.
And before anyone chimes about how too much exercise aerobic or strength training can be HARMFUL.
Obtaining maximal Vo2 max can only be done by performing PROPERLY executed regimen which may include:
Lots of easy ZONE 2
Periodized, small amounts of HIIT. High altitude and/or heat training
Proper recovery - with recovery training, sleep, massage, sauna, avoidance of alcohol or stress
FWIW:
“L-citrulline is more effective than L-arginine in increasing blood flow.
L-citrulline is more efficiently absorbed and converted to L-arginine in the body, leading to higher plasma L-arginine levels and enhanced nitric oxide (NO) production. This is due to L-citrulline’s lower first-pass metabolism compared to L-arginine, which is extensively metabolized by intestinal and hepatic arginase, reducing its systemic availability.[1-3]
Studies have shown that L-citrulline supplementation increases NO production and improves microcirculatory flow more effectively than L-arginine. For example, L-citrulline supplementation improved NO production and microcirculatory flow in a murine model with enhanced arginase activity, whereas L-arginine did not.[4] Additionally, L-citrulline has been shown to improve endothelial function and blood flow in various clinical settings, including exercise performance and cardiovascular health.[5-6]
In summary, L-citrulline is more effective than L-arginine in increasing blood flow due to its superior absorption and conversion to L-arginine, leading to enhanced NO production and improved vascular function.”
" In conclusion, these results suggest that short-term Cit, but not Arg, supplementation can improve blood pressure."
I think that Kaatsu claims that their blood flow restriction bands increase VEGF “Data from research at the University of Tokyo Medical School Hospital’s 22nd Century Medical Center from the Ischemic Circulation Physiology Department found that KAATSU leads to the secretion of Vascular Endothelial Cell Growth Factor (VEGF).”
Stephanie Seneff is open minded and brilliant and I had heard her talk about how sulfate makes the blood flow. Cholesterol sulfate deficiency is the cause of heart disease. This is what she said and I’ve spent years looking for a better, more thorough explanation of this. So here are a couple videos, first one is Stephanie herself, second is a student of hers or at least a big fan and he spends the time to explain in a way that a less educated person such as myself can understand. Talking again about Zeta potential is important and a long discussion about the glycocalyx and it seems to come down to Sulfate.
And I’m really wondering whether DMSO does it’s magic by improving blood flow by hacking the sulfate system. Have they tried DMSO in the million molecule challenge, or on mice anywhere. I know it’s too much to ask for the ITP.
A Healthy micro-vasculature is a factor that attenuates the aging process of organs. Historically, there has been more focus on the macro-circulation and arteriosclerosis. There are related links in this thread. I hope this Isareli research gets more attention.
I’ve never heard of this woman, but it seems odd that she’s a computer scientist. I have lots of friends who are computer scientists out of MIT, and while they are very smart people I wouldn’t trust anything they said about health issues. The issue of her discussion cholesterol sulfates seems more than a little out of her lane of expertise…
Seneff and her MIT colleagues have also published on the health impacts of fat and cholesterol consumption in America. Based on this work, Seneff claimed that Americans are suffering from a cholesterol deficiency, not an excess.[20][21] In 2014–2016 Seneff was proposed as an expert witness for litigators seeking damages from Pfizer associated with their cholesterol drug Lipitor,[22] but the court dismissed the claim largely because Seneff lacked expert status and failed to provide credible evidence linking Lipitor to any specific harm.[23]
Stephanie Seneff? No thank you. There are much better sources of information and science. Her work has nothing to do with established methods of science.
I believe that one of the mechanisms of action of autologous plasma injections is by increasing VEGF.
I take citrulline daily as well as Captopril. I used to alternate daily between Losartan and Enalapril to try to capture the benefits of both. When I told my GP I thought he was going to have kittens in the corner! :)) LOL
Nowadays it’s just Captopril. It’s crazy cheap where I am, too; about $1/pack.
When I see “structured water” I’m not going to listen to that person.
If they are willing to promote a scam like that, there is no credibility left in that person. While they may also promote something else that has validity, by promoting 1 scam it taints them as an unreliable source of information.
Plasma levels of cholesterol sulfate are elevated in clinical conditions such as hypercholesterolemia and liver cirrhosis.11 Because cholesterol sulfate is present in the atherosclerotic lesions of human aorta4 and plasma levels are increased in hypercholesterolemia,11cholesterol sulfate may play a role in atherosclerosis. In this study, we show that cholesterol sulfate is a substrate for platelet adhesion and may thereby contribute to the prothrombotic potential of atherosclerotic lesions.
Due process. I’ve read the AHA article. Now to watch your video.
Well I hope she’s wrong about glyphosate. She really hates it. I hope she’s right about cholesterol. Also it would be good to find out whether vaccines improve all cause mortality. Big controversy there.
I admit I didn’t do even the quick check you guys did to find out her specialty. I was too busy trying to decide whether it makes sense that electrical charge pulls the blood. It may be true, but seems a crazy method because the charge has to be brought back eventually. Nothing is free.
