“(Glycine and melatonin respectively inhibit cancer cell growth but together they do diddly — anyone?)”
That was my incorrect conclusion. My apologies for the misleading post. I corrected it in that post, after I reread the article. The decreases in tumor volume are as follows:
That is a decrease in tumor volume of
63.2% for melatonin,
43% for glycine; and
47.7% for the combo.
The combo did not potentiate the effect, but there still was an effect, higher than glycine alone. There are other benefits to glycine, other than reduction in tumor volume; reduction in glycate hemoglobin, for instance, and reduction of systolic blood pressure.
More of these Rejuvenation Olympics people are creating their own websites… another here (if you find any others, please post them):
Interesting… she’s not just relying on optimizing his current body:
Full Body Replacement: I believe this is the solution to reset life and live for centuries, whereas our biohacking is only for years. Raising Series A, 500k min - If you’re interested in revolutionzizing the human species and investing
Wow - just discovered she’s in San Francisco. I’ll have to have a chat with her over coffee… I’m surprised how well she’s doing given the minimal number of interventions she seems to be doing…
Wow. That’s a ton of supplements. However I’m surprised his only medication is Rapamycin. I’m surprised there’s no Acarbose, empagliflozin, Metformin, Bempedoic Acid, Ezetemibe, etc…
I don’t think metabolically healthy people need these. Acarbose is benign enough I guess, it is just mimicking a slow carb diet. But again what they do is possible with small lifestyle interventions.
I think all of them are useful for metabolically healthy people with maybe the exception of Metformin. You can never be too healthy to lower blood cholesterol. I don’t know how many times I have seen a very healthy person struck down by a stroke or heart attack. It just doesn’t show on the outside.
But yes understand what you mean. But I think that metabolic health and ASCVD can be better managed with physical activity and dietary interventions. And again there is no medicine that does not have side effects.
The healthy people I’m thinking of usually had a heart attack during their daily run or while playing sport. So, no, I don’t think exercise cures all ills… Especially cardiovascular issues.
Stress, high blood pressure (even occasional spikes probably) etc. all contribute. Amount of saturated fats, body fat, processed foods, sugar… sure you can take medicines to alleviate some of this… will it be as beneficial?
With physical activity you need to do the right activity for longevity. Building muscle beyond strength benefits and preventing sarcopenia or excessive sport is not beneficial in long run I suppose.
I also made a personal calculation, that I am not willing to give up occasional slice of bread, pasta, morning croissant and I compromise with acarbose. It is benign enough.
@eli i use mouth tape during sleep. It’s an easy way to increase nasal breathing (deeper breathing, filtered air, no dry mouth) for improved co2 tolerance and then higher NO and co2 for higher HRV, lower BP, and improved O2 exchange. I try to nasal breathe as much as I can. Taping is the only way to ensure nasal breathing while asleep.
Do it every night, before shuteye. I used to snore (family members noted). Not anymore (according to family), even when I forget to tape the mouth.
There is a lot of literature about nasal breathing and its benefits. There are some posts here. Just use the search string “mouth, tape”. One of the threads is below.
I do not tape the whole mouth; just the center, from philtrum to below the lower lip. I use ordinary Scotch tape. It does not impede breathing, but does not come off as well. I know, because when I pee in the wee hours, it is still there. Then I take it off, to put the early morning melatonin under the tongue. I put back the same tape, and it is still on the lips when I wake up to get up.
This lady is extreme. She uses tape even when not asleep, to force herself to nose breath.
MY PRE-EATING LIST:
• Wakeup without an alarm, breathe through nose, get natural sun
• Tape mouth with medical tape ($7.49) when not eating or socializing.
Wondering if I should try this while browsing on the computer.
I find that Dave Pascoe at 61 looks much much better than Bryan Johnson does in his mid forties, Actually, I find Johnson’s appearance weird, as though he had died and been embalmed. For me, Bryan Johnson has no real credibility. I will read what he has to say looking to possibly pick up a good idea or two. I find what Pascoe has to say many times more valuable as Pascoe lives what I consider a normal life. I also consider it an important fact that Pascoe (unlike Johnson) is not looking to sell me “miracle olive oil” and “miracle supplements” and “miracle foods” at prices many times more than they should cost. Some times I think Johnson is just trying to make another 900 million dollars as he did with his first business.
I’ve come across a few supplements on Pascoe’s list that I was not familiar with. Particularly TAM-818 and TA-65, both of which are supposed to improve telomere length.
Have you seen the price of these items? We’re talking $800 and $569 respectively for 90 days supply. That seems like a hell of a lot of cash to throw at interventions that I can find very little about and have never heard about from any other longevity experts. What’s the general feeling from everyone here on these particular supplements? Anyone tried them at all?
AIUI Telomerase is produced in cells with a high level of acetylation, probably at some particular stage in the cell cycle.
Histone acetyltransferases (HATs) and HDACs induce the acetylation and deacetylation of chromatin histone or non-histone proteins respectively, thereby modulating the expression or function of their targets. Histone acetylation or deacetylation has been shown to be associated with hTERT transcription and they seem to be a general underlying characteristic of human normal cells, telomerase-negative immortal cell lines and cancer cells [34, 94, 95]. Besides, core histones hyperacetylation at the hTERT promoter region is also related to its transcription in multiple human cells [14, 96]. Treating telomerase-negative cells with the histone deacetylase inhibitor (HDACi) TSA causes hTERT mRNA upregulation and telomerase activation. In addition, MAD-mediated repression of the hTERT promoter requires histone deacetylase activity, whereas TSA-mediated derepression is not dependent on E-boxes [94]. Moreover, Won and colleagues show that SP1 and SP3 can interact with the hTERT promoter region, and recruit HDAC to deacetylate the nucleosomal histones and silence hTERT transcription in normal human somatic cells [35].
Yes - this is an example of one of those expensive but minimal/low benefit type of supplements that people buy. The evidence that I’ve seen does not support or justify the expenditure of that amount of money on these products.
I think we really need to focus on the cost effectiveness of longevity therapeutics… what is the cost and the measurable, proven benefit? And then prioritize them based on this metric. Its easy to spend thousands of dollars on low benefit, poorly proven supplements or drugs or therapies… but thats not really the way to go unless you have unlimited resources because you’re wasting money that could be spent on more effective products/therapies.
The only thing I recall is my sleep breathing rate falling when mouth taping. It follows that a slower rate of breathing means a deeper pattern of breathing. Deeper and slower breathing is a known cause of higher co2 (leads to higher NO and more efficient O2 exchange) and higher HRV due to parasympathetic activation.
Do you use any nighttime tracker product - Oura, Fitbit, etc. - that might give more details on the “Taped” vs. “non-Taped” situation? I think I will try this in the future.
What type of tape do you use? I’m assuming a big piece of Duct Tape is not what you are using
