This site lists optimal ranges for most if not all biomarkers, including with citations, including how to prepare for blood tests and the calculator on the site is based on the Bortz Blood Age paper published in the scientific journal Nature Communications Biology from 2023. It’s 11% better than PhenoAge.
Excellent site to explore optimal values for individual blood markers. I appreciate the effort that went into gathering the data and producing tools to help us optimize our biomarkers.
One of the main benefits of the site is the ability to explore our individual markers and see how much effort we need to improve them. For example, improving Cystatin C is more important for most people than fasting glucose. We have countless posts about improving fasting glucose as compared to cystatin C posts.
As for the Humanity’s Bortz Blood Age Calculator, the test accuracy is unknown for people older than 73 years. This is unfortunate because there are many members of the forum that are older than 73 years.
The 11% increased accuracy would only make it differ from the Levine model by less than 2 years for most of us.
So, for fun, I put in my latest test results into the Levine calculator. As I understand it now, the biological age is more of a predictor. In other words, if I am 80 and the calculator indicates that I am biologically 70, I would have a mortality prediction of an average 70-year-old, not that I have the body of a 70-year-old. Correct me if I am wrong.
My latest:
So, I have a 75% chance of living another 10 years?
Here’s the different markers in Bortz Blood Age sorted by importance (red means higher is worse – while blue higher is better). It’s always when all other markers are equal, so higher creatinine is only better if cystatin c didn’t change – because it’s a marker of higher muscle mass in that case, for instance.
I’m ~12 years under my 81 chronological age too @desertshores. according to the narrative, the largest single reduction I can make (more than the other four combined) is lowering Cystatin-C. Last month is the first time I measured it but I’m not sure how much it can be improved.
My comment related to lowering Cystatin-C was poorly expressed. The accepted view is that most kidney functions cannot be increased but specific actions can slow the rate of decline. Those of us who have BP at least at the mid-point of the target can benefit in multiple ways by taking an ARB like telmisartan, keeping in mind that they lower eGFR by 15-20%. (The fact that this decline results in improved kidney health requires explanation to someone looking at that fact for the first time.) The next level of intervention is an SGLGT2 inhibitor, which further lowers eGFR and preserves kidney function.
