Autophagy, Gene Length and Aging (why Senolytics don't work that well)

I have done some analysis based upon the review on autophagy and I think I now know why senolytics don’t work that well.

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Question for John. Would you expect senolytics to have a greater benefit for certain tissues based on long gene involvement? I also wonder if most of us are not optimizing the use of Rapamycin to promote autophagy. Perhaps every other month dosing combined with fasting and zone2 training would be better than weekly.

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I think clearing aenescent cells is generally a good. However, targeting specific tissues is not necessarily that easy

I agree with the idea of using rapamycin to target cycles of autophagy potentially combined with other tools such as fasting. I think weekly is too frequent.

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This is a bit of an overlap paper that I have just found:

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan