Hey Walt,
David Sabatini, the authority on how rapamycin works, says MTOR is in all cells even in red blood cells (RBCs) and platelets.
Hence, through MTOR, autophagy is occuring in all cells. Average adult male has around 36 trillion cells in their body, while average adult females have 28 trillion.
Apparently there are 3 different types of autophagy, its not even clear which rapamycin is triggering.
I feel like we are either on the bleeding edge of biological research or out in the weeds with taking rapa considering what little about this compound outside or mouse models and orgran transplants.
Do we know if there is any active real research happening today?
Hahaha… sorry… no intention of offending. Your profile says Walter… so why not Walt.
Your article on autophagy is 10 years old… maybe more information since? As you wrote… anything new?
And yes… it is a bit like flying in the dark… but with competent researchers like Blagosklonny, Kaeberlein and physician Attia all taking it for years… I have a degree of confidence. And, as a user of 3.5 years, I have seen enough improvements in myself physically and through biological tests to believe it is more than wishful thinking. Also, seeing evidence in old dog’s improving and multiple physician friends… too much is there for it to be nothing.
Whether you take rapa or don’t take it… up to you. Good journey.