Are Sex Chromosome or Sex Hormones Driving Aging?

Which mice live longer, XX with ovaries, XX with testes, XY with ovaries, or XY with testes? The answer, according to Dena Dubal in the second half of this podcast, is XX with ovaries, leading her and fellow researchers to conclude that the longevity is both a function of the sex chromosomes and the consequent sex hormones, and the combined effect is more than either independently.

Does this have anything to say about hormone replacement therapies and longevity? Does the weak estrogen 17 alpha estradiol extend longevity of male, but not female, mice because females already have similar or greater estrogens?

As noted in below, there are many differences in how males and females respond to anti-aging interventions.