Now that even Sinclair has RT’d ketamine slowing epigenetic aging…
There are potential arylcyclohexylamines/“dissociatives” that are even more effective. MXE is one (hard to source now, but synthesis may become easier later)
[other examples include O-PCE, Mxipr, FXE, etc]. I have noticed that they are often more popular than traditional psychedelics, esp b/c they are less likely to be scheduled and way more tolerable/lucid than traditional psychedelics (much less likely to make people “crazy” than non-DMT psychedelics).
They are very experimental so there is always “experimental risk”, but if I were to make a guess, I would think that many (esp MXE) are less risky than ketamine. Also, them being mostly unknown makes the chances of a “very positive outcome” to one more likely than more known compounds.