I like the idea of this thread that Karl started on Twitter… Please add your thoughts:
Source: https://x.com/KarlPfleger/status/1769766685060337812?s=20
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I like the list, again I don’t agree with Karl’s implicit assumption that plant based diets are healthy because of low taurine, why not in spite of?
I lean on the more low protein end of the spectrum and believe the science will bear that out in the future. My theory for high protein potentially having benefits for old age is when a population is sick/frail they have different nutritional requirements (haven’t heard the statistical fluke idea he mentioned). If you are in good health I suspect lower protein will be better but when you’re trying to keep weight on an elderly relative you go for the chicken pies and ice cream etc.
Same with mtor, most of the time you want it low, occasionally you want it high.
Again with oxygen I would guess lower is better, people at altitude tend to live longer but we have many confounding factors. Oxygen therapy used to be far more widely used in medicine than it is now as people have become aware of the risks it poses.
I think with almost all of the things he listed a rule of thumb will emerge in the next decade or so you follow 95% of the time and special cases make up the other 5%.
If you copy what long-lived populations do it may not be optimal but it probably won’t kill you.
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There are studies discussed elsewhere that show that rapamycin helps preserve muscle mass despite lowering mTOR. So I’m counting on rapamycin and generally low inflammation to allow moderate protein (75g/day) and weight training to preserve muscle mass. Occasionally I’ll have a much higher protein day (say 150g) and do more weight training, and other times I pair moderate protein with BCAAs and weight training. No problems so far at age 60
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