A lot of functional tests like exercise and reaction time are practice related.
The key issue I look at is the function of the genome. That is a dimension orthogonal to practice.
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You are supposed to take in around a total of 10-20,000 pg total (30-40k if you smoke) and then once you downregulate you stop taking it except for monthly maintenance micro-dose. You probably took in 60,000pg. Taking too much gdf11 can be just as bad as too little.
The dose makes the poison. I would consider DNP at doses much lower than those traditionally used for weight loss.It may extend lifespan in mice: Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity - PubMed
Low doses of DNP have hormetic effects that may be beneficial for some diseases:
The positive effects above are generally seen at doses far lower (roughly 10-100 times lower) than those that result in noticeable weight loss.
I would actually like to see DNP tested in the ITP.
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It was – didn’t work, any thoughts?
Published May 2024:
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Thanks. I didn’t know DNP had already been tested by the ITP. The results are disappointing. I notice that in the ITP study they used at least 5 times higher dose than the dose that was used in the earlier study that found extension of median lifespan. So it’s possible the dose used in the ITP study was too high, but I’m not sure. I haven’t researched this in detail.
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Paul, I read through Steve Perry’s information and Turnbuckle’s information quite some time ago (more than once) and found none of what they said to be very compelling at all. I even watched Perry in his RAADFest 2022 GDF11 Presentaion. My thoughts about Perry always brought to mind the term “snake oil salesman.” However, I do still have interest in epitalon. So, post your thoughts when you have time, whether good or bad. Thanks.
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Hi Jay
I carefully tracked my biometrics every day and blood work quarterly and never found the improvements he proclaimed. My sense is that GDF-11 was a wild goose chase and not the blood factor that is controlling aging. I did get a nice spreadsheet out of the experience which I keep up to this day over 5 years later.
It would be quite informative to know the cause of his death. He was taking klotho as well at the time.
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I think we can all agree that Perry died way too young, so something either went horribly wrong or he was incredibly unlucky.
I remember him talking about how the dosing on GDF-11 was very difficult to get right and a little bit too much could have very negative effects. I wonder if this is what did him in.
In the end, Im not touching GDF-11 with a ten foot pole until more data comes out in favor of it.
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