I used Urolithin A from Do Not Age for several months. Didn’t notice any positive or negative effects. Didn’t notice anything from Mitopure either. Nestle is trying to stop anyone from selling Urolithin A.
Urolithin A sounds good on paper, but I haven’t seen anything that moves the needle for me to want to buy it. Too many other supplements trump it. And, it’s pretty expensive. I’d rather place other cheaper bets, like ergothioneine and boron.
Started with UA and 4 other “exotics” 3 months ago.
Will be doing a 7 month eval and in Sept will do our 5th DNAm test to see if the needle(s) moved and in which direction.
Of course this is a severely compromised eval as adding 5 things at once is not terribly “scientific” but at 68, time is of the essence
I think one of the ways some companies are getting around the IP issue is to combine UA with other compounds. At least that is my theory for now Most of the patents I’ve looked at are production related but some are more convoluted.
Interestingly, the more complex a patent is, it’s often easier to go around it.
Hi @WJ_PhD I’ve tried Mitopure but agree its expensive.
A couple of months ago I bought 30g Urolithin A from Aeternum UA. This is an Australian (Queensland) company - I paid A$100 (US$66). I’ve checked out the company and they seem legit and they have published a HPLC certificate of analysis (look at the last image).
The product arrived professionally packaged but its not unwrapped yet. I have no affiliation with this company and I’m not endorsing Urolithin A, but the compound seems interesting. I won’t get around to testing it myself until I’ve cycled off, and cleared, other compounds. That is at least a coupe of months away. I’m strict about not mixing too much together.
Update: I found this review of Urolithin A. There’s video of the potential benefits and effects.
I have tried the Aeternum one as well as Mitopure. I think I noticed sleep problems from Aeternum (which to me is a positive sign of mitophagy). My sleep has improved a lot in the round, but goes in a cyclic manner worse when I take Rapamycin.
I would love to do testing every 2 months but that is not in my budget t the moment, every 9 months is the best I can do for now. So that time restriction affects my feedback loop
Do you combine Urolithin with Rapamtcin? I was taking it for a while but quit when I started Rapa. They seem to do the same thing, eg, eliminate old cells and stimulate mitochondria. I was also taking Long Pepper, another senolytic, which I also stopped. Should I wait to see my results with the Rapa before adding them back?
The recent systematic review, I actually consider Urolithin A is one of the most worthwhile supplements to take, ranking at least in the top two or three.