Anyone here tried Mounjaro + Rapamycin together?

#1

Dear all,

I’ve been on Mounjaro for about 3 weeks now — down 4 lbs so far. My goal is to get back to 195 lbs (currently 215). Planning to start Rapamycin in a few weeks, taking it pretty moderately.

Just wondering if anyone here has run both at the same time — Mounjaro (tirzepatide) and Rapamycin — and what kind of results or side effects you noticed, good or bad.

I’m in my 60s, male, hoping to hit my target weight and eventually taper off tirzepatide once things stabilize.

Would love to hear any real-world experiences or tips from those who’ve tried this combo.

Thanks!

Pat

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#2

I didn’t find rapamycin interfered with weight loss from tirzepatide.

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#3

All the time with no issues.

Most people take short high weekly or bi-weekly doses (in the range of 3 to 8mg per dose) of Rapa, which I was doing for several years.

A few months ago I switched to low daily dosing of 1mg per day. No issues.

For over 2 years I’ve been taking a GLP1 - I have used Tirz and switched to Retatrutide for the past 16 months. I like that one better for maintenance.