Any experience with Pioglitazone (Actos)? Apparently it's great for insulin resistance

CronosTempi · August 11, 2025, 12:21am

[This post is a bit of a grab bag of disparate studies with pioglitazone, simply a way around posting limits od separate posts, so I just keep amending this post to add further studies without bumping up against the limit - apologies for the scattershot effect.]

Empagliflozin and pioglitazone do not appear to have adverse DDI (drug drug interactions), at least short term. Why is this important - because this was in healthy people.

Pharmacokinetics of Empagliflozin and Pioglitazone After Coadministration in Healthy Volunteers

Regarding bladder cancer and lack of treatment options - progress is being made:

New treatment eliminates bladder cancer in 82% of patients

CV health and pioglitazone:

Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials

Association of Pioglitazone With Major Adverse Cardiovascular Events, All-Cause Mortality, and Heart Failure Hospitalizations: A Systematic Review

This is an interesting paper on genetic variability affecting pioglitazone:

Current clinical evidence on pioglitazone pharmacogenomics

More on AD and pioglitazone - it’s complicated!

Reassessment of Pioglitazone for Alzheimer’s Disease

A_User · September 26, 2025, 12:00am

Here was the largest interventions minimum 1000 people while using the search term “pioglitazone” on clinicaltrials.gov:

Study Title Study URL Enrollment

Action to Control Cardiovascular Risk in Diabetes (ACCORD) ClinicalTrials.gov 10251

Efficacy of Pioglitazone on Macrovascular Outcome in Patients With Type 2 Diabetes ClinicalTrials.gov 4373

Insulin Resistance Intervention After Stroke Trial ClinicalTrials.gov 3876

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer’s Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset ClinicalTrials.gov 3494

Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial ClinicalTrials.gov 3371

Safety and Efficacy of Empagliflozin (BI 10773) and Sitagliptin Versus Placebo Over 76 Weeks in Patients With Type 2 Diabetes ClinicalTrials.gov 2705

Safety and Efficacy of Vildagliptin vs. Thiazolidinedione as add-on Therapy to Metformin in Patients With Type 2 Diabetes Not Controlled With Metformin Alone ClinicalTrials.gov 2665

Safety and Efficacy of Linagliptin (BI 1356) as Monotherapy or in Combination in Type 2 DM ClinicalTrials.gov 2122

Safety Study of Pioglitazone Compared To Glyburide on Liver Function ClinicalTrials.gov 2120

Study of Rivoglitazone in Type 2 Diabetes Mellitus ClinicalTrials.gov 1912

MK0431 and Pioglitazone Co-Administration Factorial Study in Patients With Type 2 Diabetes Mellitus (0431-102 AM2) ClinicalTrials.gov 1615

Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus. ClinicalTrials.gov 1554

Effect of Pioglitazone on T2DM Patients With COVID-19 ClinicalTrials.gov 1506

A Phase III Study of BMS-512148 (Dapagliflozin) in Asian Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone ClinicalTrials.gov 1484

Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone ClinicalTrials.gov 1462

GALLANT 6 Tesaglitazar vs. Pioglitazone ClinicalTrials.gov 1450

Study of Muraglitazar Versus Pioglitazone in Type 2 Diabetes ClinicalTrials.gov 1440

Thiazolidinedione Intervention With Vitamin D Evaluation ClinicalTrials.gov 1332

A Phase 3 Study of BMS-477118 in Combination With Metformin in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise ClinicalTrials.gov 1306

A Study to Evaluate Combining Metformin With Muraglitazar or Pioglitazone in Type 2 Diabetics ClinicalTrials.gov 1159

GALLEX 6: Study to Evaluate the Safety and Tolerability of Tesaglitazar in Patients With Type 2 Diabetes Mellitus ClinicalTrials.gov 1100

Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes ClinicalTrials.gov 1006

Study on MAFLD-related Cirrhosis Prevention and Treatment Strategies ClinicalTrials.gov 1000

Study Title	Study URL	Enrollment
Action to Control Cardiovascular Risk in Diabetes (ACCORD)	ClinicalTrials.gov	10251
Efficacy of Pioglitazone on Macrovascular Outcome in Patients With Type 2 Diabetes	ClinicalTrials.gov	4373
Insulin Resistance Intervention After Stroke Trial	ClinicalTrials.gov	3876
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer’s Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset	ClinicalTrials.gov	3494
Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial	ClinicalTrials.gov	3371
Safety and Efficacy of Empagliflozin (BI 10773) and Sitagliptin Versus Placebo Over 76 Weeks in Patients With Type 2 Diabetes	ClinicalTrials.gov	2705
Safety and Efficacy of Vildagliptin vs. Thiazolidinedione as add-on Therapy to Metformin in Patients With Type 2 Diabetes Not Controlled With Metformin Alone	ClinicalTrials.gov	2665
Safety and Efficacy of Linagliptin (BI 1356) as Monotherapy or in Combination in Type 2 DM	ClinicalTrials.gov	2122
Safety Study of Pioglitazone Compared To Glyburide on Liver Function	ClinicalTrials.gov	2120
Study of Rivoglitazone in Type 2 Diabetes Mellitus	ClinicalTrials.gov	1912
MK0431 and Pioglitazone Co-Administration Factorial Study in Patients With Type 2 Diabetes Mellitus (0431-102 AM2)	ClinicalTrials.gov	1615
Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus.	ClinicalTrials.gov	1554
Effect of Pioglitazone on T2DM Patients With COVID-19	ClinicalTrials.gov	1506
A Phase III Study of BMS-512148 (Dapagliflozin) in Asian Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone	ClinicalTrials.gov	1484
Study Assessing Saxagliptin Treatment In Type 2 Diabetic Subjects Who Are Not Controlled With Metformin Alone	ClinicalTrials.gov	1462
GALLANT 6 Tesaglitazar vs. Pioglitazone	ClinicalTrials.gov	1450
Study of Muraglitazar Versus Pioglitazone in Type 2 Diabetes	ClinicalTrials.gov	1440
Thiazolidinedione Intervention With Vitamin D Evaluation	ClinicalTrials.gov	1332
A Phase 3 Study of BMS-477118 in Combination With Metformin in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise	ClinicalTrials.gov	1306
A Study to Evaluate Combining Metformin With Muraglitazar or Pioglitazone in Type 2 Diabetics	ClinicalTrials.gov	1159
GALLEX 6: Study to Evaluate the Safety and Tolerability of Tesaglitazar in Patients With Type 2 Diabetes Mellitus	ClinicalTrials.gov	1100
Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes	ClinicalTrials.gov	1006
Study on MAFLD-related Cirrhosis Prevention and Treatment Strategies	ClinicalTrials.gov	1000