Any evidence-based ideas for severe sciatica/radicular pain in a 77-year-old? Rapamycin, LDN, montelukast, ARA-290, etc

#1

My father is 77 and has developed severe walking-limiting pain that currently seems most likely to be sciatica / lumbar radicular pain, though PAD has not been fully ruled out yet.

Current medical path:

  • PT is starting
  • specialist visit is already scheduled
  • I am not asking for advice that replaces proper medical evaluation

What I want to know is specifically this:

  1. Has anyone here found any actual human evidence for any nonstandard treatment that helped sciatica / lumbar radicular pain, not just generic back pain?
  2. I am especially curious about:
  • rapamycin / sirolimus
  • low-dose naltrexone (LDN)
  • montelukast
  • ARA-290 / cibinetide
  • anything else with a plausible anti-inflammatory or nerve-repair mechanism
  1. Are there any clinical trials , published case reports, or physician-guided uses worth knowing about?
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#2

Read and have him read any of John Sarno’s books.
Potassium helps address secondary muscle spasms.

Power lifters will routinely take 1/2 teaspoon of Himalayan sea salt every 1/2 hour with 8 to oz of water until the pain resolves.

Mineral water boosts electrolytes and helps with dehydration the can desiccate disks between vertebrae.

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