Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

#1

https://www.science.org/doi/10.1126/sciadv.adp4119

“Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not separate the intestinal epithelium from the microbiota…. Thus, antibiotic use might predispose to intestinal inflammation by impeding mucus production.”

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#2

Interesting article. I wish they used different antibiotics. Neomycin and Vancomycin are poor choices to test for orally administered antibiotics. Erythromycin class would have been better.

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#3