I found it really interesting that curcurmin metabolises to ferulic acid and vanillin. (I have not read the paper),.
Nothing ever comes of curcumin. I remember seeing posters about the anti-tumor and anti-inflammatory effects of curcumin more than 25 years ago when I was in med school and in spite of these more than 2 decades of research there still isn’t a usable drug
You are fully aware.
No IP protection, no entity will invest money to get “drug” approval.
In my view
If a compound/molecule has potential and I think is has merit I will use the compound/molecule.
I do not need/require any approval from any entity.
I make my own decisions based on my review/research.
Bioavailability has always been a problem, so modifying curcumin to make it more bio available could be patentable but of these attempts nothing came either
It metabolises into vanillin and ferulic which themselves are bioactive
I think curcumin has helpful anti-inflammatory properties. However, I don’t think it’s a game-changer like Rapamycin. The only negatives I have heard about it, is that some supplies are tainted by heavy metals. Overall it’s a decent spice.
My own protocol uses quite a large number of different substances. I am not sure myself that any one substance would have that much impact. Hence Rapamycin (and I would use it far less frequently that most on this board - I have taken it once and used it topically twice in 4 months. I am doing a lot of testing which has not left that much space for Rapamycin, but I intend taking it again in 2023 (possibly more than once).
When you take it occasionally, what is the dose?
6mg mainly because that is a packet of 6x1mg pills
I think i have taken it 4 times this year but not regularly. I tend to plan something such as a fast or use of cgm and time the rapamycin for that.
John, it seems that you are not concerned that mTOR rebounds during your lengthy breaks. Is it the case? Could you explain why?
If you are taking Rapamycin chronically to reduce the effect of the immune system it is, of course, possible that your systems respond such that if you stop taking Rapamycin then there is a greater mTOR response.
In essence I am taking Rapamycin a few weeks after it has cleared from my system. I am not taking a massive dose although 6mg is not minute.
I have seen no evidence that would suggest that I might see an mTOR rebound.
In any event my objective in taking Rapamycin is to inhibit mTOR for a period to encourage autophagy and improve the quailty control specifically of my mitochondria.