Interestingly it should stabilise at the sort of serum level that a 1 off dose of 8mg peaks at.
I have spent quite a bit of time looking at angioedema because that is something that is low risk, but potentially a high hazard. I think things like that occur when mTOR is inhibited over a period of time.
My single high dose may have caused a single acne spot, but I have intermittently had acne over my life anyway so that may not have been the cause.
However, continually inhibiting mTOR will have a number of negative effects.
I still think personally I want a period when mTOR functions entirely normally.
While I did suggest GLP1-r’s it’s for a variety of reasons, not just weight There are probably more short and long term benefits from this class of drugs than from Rapa IMHO.
I think there is more evidence due to the mass of data on GLP1’s. We’d need an equivalent amount of data on Rapamycin to have any idea. I don’t see that forthcoming rapidly.
I’ve been taking GLP1’s for far longer than Rapamycin. While on GLP1s and Metformin, A1C had been under 6. Once I started taking Rapamycin, it did climb a bit over 6 on the first blood test. Waiting to hear what the next one shows.
The next big thing we need is something to address muscle loss.
Curcumin inhibits rapamycin uptake, possibly through CYP3a4 overexpression (opposite of GFJ), although this is somewhat controvercial, studies in vitro or animal models, not as clear in humans. If so, it’s probably time limited to a 6 hour window or so, so one could theoretically take rapa and turmeric 8 hours apart. However that assumes going into the digestive system without any interference from other substances which may affect the timing. I’d rather not take the chance, so I intend to drop curcumin altogether, it’s a very dirty supplement anyhow (interacts negatively with glucosamine f.ex) and there’s not enough insight into how it works. Given the choice, I’d rather protect my rapa intake, and not take a chance.
I took curcumin 2 hours after my last rapa dose (and I normally take it about 2 hours after rapamycin, but rapamycin say 22 hours after curcumin). I know rapamcyin is currently having an effect because my blood glucose handling has shifted quite a bit.
@rberger your 15 minutes is not up yet it seems… They go off on many different tangents, and don’t understand it’s a generic drug, so not very well informed opinions…
Move over Botox: A drug used for transplant patients may help reverse aging
Nomiki Konst and Amber Duke discuss a drug called Rapamycin that some scientists say can delay aging and age-related diseases. #AntiAging#Rapamycin
Well family medicine is one of my 4 board certifications. The most relevant is my Anti-Aging and Regenerative Medicine boards. Most of my practice has been Emergency Medicine. Anyway, having a diverse perspective on life and having done everything from delivering over 200 babies, to critical care in trauma centers - to now what is much more fascinating - Longevity Medicine … allows a thought process and understanding around life. The evidence is clear that if we can slow epigenetic aging, all the bad things that happen to humans will be delayed, giving years of additional quality life.
Do people actually still believe the New York Times is a reputable newspaper? They’re one of the worst perpetrators of fake news and propaganda out there
What in the rapamycin article do you find that is false or fake? Its always easy to be a critic.
The story was more conservative than I would have liked, but they didn’t get any facts wrong from what I could tell, and its reasonable to be cautious when you have an audience of 10 million people. All the articles that we’ve seen in the much-disparaged main stream media on rapamycin have been pretty accurate from what I can tell. All these mainstream providers do a reasonably good job of science reporting, which is more than can be said for many sources.
I think all major news sources are pretty good at reporting scientific news so long as there is no special interest and big money involved. I don’t see how anyone could benefit from Rapa (a generic drug) unless @RapAdmin is so loaded with cash that he goes around and pays millions$ to these major newspapers to advance the Rapa cause so on this one, I think you are wrong @Elros
That’s far from true. I don’t know how anyone could say that with a straight face unless they have very limited news sources and even then… All newspapers, even NYT, have spin and are influenced by outside sources, usually financial pressure, to put extra emphasis on certain things - but that’s far different from fake news. Ever seen a tabloid? Or for propaganda, there’s plenty on both the far left and far right. We all need a filter to understand that all media has a bias but if you think that NYT is one of the “worst perpetrators” then your filter is not good.
There are probably more short and long term benefits from this class of drugs than from Rapa IMHO.