We further examined the roles and functions of the 20 proteins comprising the ProtAge20 score, which together capture ~95% of the 204-protein model’s ability to predict age. These key APs are involved in (1) cell adhesion and extracellular matrix (ECM) interactions (ELN, COL6A3, CDCP1, PODXL2, LTBP2, SCARF2 and ENG); (2) immune response and inflammation (CXCL17, LECT2, SCARF2 and GDF15); (3) hormone regulation and reproduction (FSHB, AGRP and ACRV1); (4) cell signaling (EDA2R, SCARF2 and PTPRR); (5) protease activity and enzymatic function (KLK3 and KLK7:); (6) regulation of body weight and energy balance (GDF15 and AGRP); (7) neuronal structure and function (GFAP and NEFL); and (8) development and differentiation (EDA2R, LTBP2 and ENG).
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