As discussed in earlier posts, GF mainly affects the absorption, not the elimination of rapamycin, and I believe absorption is complete within the first hour on an empty stomach or maybe a few hours with food (give or take). The inhibition of CYP 450 by GF lasts more than long enough for this absorption period.
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Oh wow awesome okay. I felt far more clear-headed today than all previous days
3 LBS OF APPLES spread throughout the day. SGLT2 inhibitors are awesome. Only concern is that they might not work on fructose which isn’t even measured
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any side effects since taking the high dose?
None
Tried 12.5 mg empagliflozin with 2.4 lbs of apples today
First spike after 2 apples, all other spikes are barely noticeable
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Yep, one of the best anti-aging drugs = exercise = inflammation/oxidative stress. @AlexKChen curious - when was the last time you did resistance training?
Antioxidants =/= good. We know some antioxidants may lead to higher death rates. Guess the old paradigm doesn’t die easy. I still remember the craze back then about antioxidants when it was clear there was a lack of evidence. Meanwhile, I just focused on low hanging fruit diet/exercise/sleep.
“Antioxidant supplements are not associated with lower all-cause mortality. Beta carotene, vitamin E, and higher doses of vitamin A may be associated with higher all-cause mortality. Therefore, our review does not support the use of antioxidant supplements as a primary or a secondary preventive measure.”
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I took a very long break from the thing but am going back on it to see empagliflozin, semaglutide, and fruit effects
25mg empagliflozin 12 hr ago did not prevent a peak of 240 calories diced tomatoes from raising BG to 148. And these are just diced tomatoes…
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The studies I have looked at show benefits for those who already have type II diabetes or already have some forms of CVD, but there is not much info on it having much of a preventative effect.
I have been taking it for about 5 months and have noticed zero effect on my fasting glucose. And, you are right it does not seem to prevent spikes. When my current supply runs out I don’t think I will order it again.
I am currently taking acarbose for its longevity promise and for preventing glucose spikes and I have been taking metformin for decades for both its longevity properties and blood glucose control. Acarbose definitely reduces glucose spikes but has had zero effect on my fasting glucose.
So you stopped taking Empagliflozin for a long time?
Hope you’ll want to keep updating about the effects you are seeing on your BG levels.
No, I am still taking it. I just won’t be re-ordering when my present supply runs out. My glucose levels were acceptable before I started taking it. I had hoped it would have an effect on my fasting glucose levels which I would like to lower to the low 90s mg/dL. It had no effect that I could detect. Yes, I am self-testing daily and have lab tests every 6-8 weeks.
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One mango spiked from 73 to 98 then down. Ate with both acarbose and empagliflozin. acarbose has half-life 2 hrs, empagliflozin 12 hrs.
Morning spikes may be worst bc low insulin
Then 1 hr later, I ate one banana after the other, which spiked my BG. Just took banana a hour after empagliflozin
This is two bananas after empagliflozin - ugh looks like empagliflozin is not reducing spiking much if at all
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How ripe are the mangoes and bananas? Aren’t they mostly fructose?
mango has more % sucrose than any fruit. not too ripe
I am going to try 50mg empagliflozin next to see if anything different happens. For me that’s ~ 1mg/kg (i am 45kg)
Pharmacokinetic analyses showed empagliflozin was rapidly absorbed after oral administration, with a median tmax ranging from 1.5 to 2.1 hours across the dose groups
These averages are not much different from prior to consuming these things…
Friend helped me order a general Tso’s tofu dish at restaurant but holy crap the spike.
I took taurine
Both spikes just from the general tso’s tofu
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@AlexKChen Alex,
Imho, I’d be careful with such high doses of Empagliflozin based on reports about potential side-effects of which the risks seem to increase with increasing doses.
770 calories of catalina crunch + 1 slimcado, zero effect on glucose 1.5 hrs in
I just looked back at this thread and I had insane insulin sensitivity back in February when I visited Colorado (even though I was VERY insulin-insensitive the turn of the year back in January). I really wonder what happened… i still remember the baguette I ate that did not increase my glucose at all. It’s worth noting that I did shrooms in Colorado, but that probably did not affect my readings. It could be relevant that O2 in Denver is 20% less than at sea-level AND there is substantial evidence that people at higher-altitudes are more insulin-sensitive (that’s why CO has such low obesity rates - maybe me growing up in CO [despite a shitty non-veg rice-heavy Asian diet in CO] is part of the necessary secret to my non-ending youth) => I do not think the effect size is that large
[FOR THREAD CONTEXT - I WAS IN COLORADO FEB16-20]. It may just be coincidence, but my incredibly amazing glucose levels in this thread coincided with those dates…
[right now my insulin sensitivity is not the worst but I get unusually large/thick spikes even with empagliflozin AND metformin AND semaglutide combined]
I am going to try peach/nectarine/granny smith apple tomorrow. Yesterday I tried mango + two bananas + acarbose, but that still spiked my BG (the two bananas did it way more than the mango). If empagliflozin is not that effective on me, I need to move onto the high-sucrose fruits w/acarbose. OH cantaloupe has high sucrose, wow…
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One dragonfruit with acarbose
Damnit
I ate two granny Smith apples yesterday and they only increased BG by 20
No recent empagliflozin
acarbose + 350 calories of mashed pinto beans = zero increase. acarbose + mango = 10 pts increase.
While I continue to test foods on this CGM, I’m going to try steel cut oats + acarbose and bread + acarbose again just so I have the full spectrum of foods (plus wouldn’t it be SO great if I actually CAN eat sandwiches again!) Not that I would eat them on my own (why eat grain when you can eat beans) but I would be able to advise other people better + be less picky when with others + know what to eat if the only choice left is between grain and low-sucrose fruit. Acarbose is cheap as dirt so this feels VERY liberating.
(this also gives a route for a very low-protein diet, since beans have more protein than grains)
Michael Gregor is also pro-grain - it would be nice for him to be consistently right enough for me to recommend him w/o qualifying.
ALSO I need to try corn, long-grain brown rice (Long Grain Brown Rice - 1lb - Good & Gather™ : Target ), and chickpea pasta
lol the pinto beans had zero effect
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The role of grains, processed & unprocessed? - Page 2 - CR Practice - CR Society Forum => I FINALLY WANT TO TRY THIS AT LAST
also I want to be able to eat yams again!