posted a lotof threads in scientific nutrition here - https://www.reddit.com/user/inquilinekea
GOD THAT RED DIP WAS SO PAINFUL BUT I FORCED MYSELF TO FAST FOR SO LONG
I would really caution against this practice , as you honestly are wasting melatonin and its completely unnecessary. Most melatonin people take are extremely higher than endogenous levels and really if you need it for insomnia or trouble falling asleep you should take no more than 1-5mg, maybe 10mg at the highest( and that’s pretty high too).
Melatonin the "light of night" in human biology and adolescent idiopathic scoliosis - PMC.
I have never seen any research in animals suggesting that spiking melatonin beyond natural peak levels results in any significant additional anti-aging benefit.
I think this article below does a good summary of some side effects of taking melatonin]
I would just really caution against this. I currently am doing my PhD in mechanisms of sleep and circadian rhythms, and honestly think this is unnecessary if you are practicing good sleep hygiene and probably are giving yourself a unnecessary risk in relation to the “gain” of taking these high levels of melatonin. I think you would be better off focusing on other aging factors and just let your natural circadian rhythm do the job for you as long as you are practicing good sleep hygiene.
Melatonin is the most potent antioxidant ever, so why not (it’s also harmless even in large doses, so some period of experimentation is fine - it’s not like I’ll religiously take it for the rest of my life).
That is a bold statement to say about being the most potent antioxidant ever. I mean there’s Glutathione , Astaxanthin , Riboflavin, etc.
Again you are going to do what you want and that’s fine, I would just caution anyone in doing the same practice as when you take a substance that impacts your circadian rhythm you will end up affecting your natural circadian rhythm. Melatonin makes sense with shift work and jet lag, but in normal adults the data on effectiveness is minimal. More than likely you will affect your natural circadian rhythm at the doses you are taking and that can cause trouble sleeping on your own. I think the benefits of good sleep far outweigh any antioxidant benefit that you would gain. Also we actually need some pro oxidant signaling in our bodies.
A Good podcast about that with Navdeep Chandel on Peter Attia’s podcast.
Again I just want others to understand the potential impacts of doing this practice, there may be minimal to no risk doing it but I think there are other things you could focus on or do instead.
There may be some benefit if you are an older adult having trouble with sleep latency and there is an idea right now that it can help combat/prevent pineal gland calcification, but more research is needed for the that.
Dr. Brad Stanfield talks about melatonin and being careful not to talk high levels in this video:
I ATE HALF A BAGUETTE AND 200MG ACARBOSE AND 200MG canagliflozin AN HOUR AGO AND…
omg ZERO INCREASE IN BLOOD GLUCOSE. I CAN EAT BREAD AGAIN
Yesterday I was able to eat some hackathon food (including a date bar and cereal w/sugar) without too much of an increase (it went up to 130 and then back down) which is good (averaging at 88 for the whole day). It’s not something I like doing or want to do, but there are periods of time when no other food is available/accessible and when I have to settle for using good timing on less healthy food (this means smaller portion sizes). I did space out 3 canagliflozin pills in one day though.
was in Colorado the past 5 days. Now I have a good idea of how much hotel cantaloupe is appropriate to eat that doesn’t shoot my BG up to inappropriate levels (sadly, only… roughly a cup at a time)…
Today I ate two 1-lb bags of peas (350 calories each) + acarbose + canagliflozin, and neither increased BG beyond 92 (also I still feel full now!) peas are a good staple food (only with the starch blockers) b/c they’re cheap, don’t need to be cooked, and people often offer them to me. Plus after reading some papers on free fatty acids, I may consider not eating too many MUFAs (it’s unclear if 2000+ calorie nut binges are healthy if you do them EVERY DAY).
just took 20 mg rapamycin with grapefruit
==
last few days: I ate 1600 calories of amy’s lentil soup all at once + acarbose (no interesting elevation in blood glucose) yesterday. I did 720 calories today and nothing interesting even after i added a lb of strawberries.
Wow, 20mg with grapefruit… So about 70mg+ equivalent. Let us know how it goes
How did you calculate the increase?
The multiplier of using grapefruit juice with rapamycin is somewhere around 3 to 3.6 suggests the research. Its hard to know exactly how much because there seems to be variability in the juice / grapefruit. See How to increase the bioavailability of rapamycin
FWIW…an experiment measuring method; measure serum blood levels like you would do a glucose tolerance test. Would cost a few dollars, base line to start, then ½ hour draw, then 1 hour draw, then 2 hours, then 3 hours at a minimum{this would cost around $500.00, based on the Life Extension $99.00 per test] You could run/draw {$99.00 per draw/test] every hour to measure what will be peak level. “Personalized Medicine”
Don’t you need to eat grapefruit continuously after the first dose to maintain the enzyme blocking though?
3 apples and then 25mg empagliflozin
As discussed in earlier posts, GF mainly affects the absorption, not the elimination of rapamycin, and I believe absorption is complete within the first hour on an empty stomach or maybe a few hours with food (give or take). The inhibition of CYP 450 by GF lasts more than long enough for this absorption period.
Oh wow awesome okay. I felt far more clear-headed today than all previous days
3 LBS OF APPLES spread throughout the day. SGLT2 inhibitors are awesome. Only concern is that they might not work on fructose which isn’t even measured
any side effects since taking the high dose?
None
Tried 12.5 mg empagliflozin with 2.4 lbs of apples today
First spike after 2 apples, all other spikes are barely noticeable
Yep, one of the best anti-aging drugs = exercise = inflammation/oxidative stress. @AlexKChen curious - when was the last time you did resistance training?
Antioxidants =/= good. We know some antioxidants may lead to higher death rates. Guess the old paradigm doesn’t die easy. I still remember the craze back then about antioxidants when it was clear there was a lack of evidence. Meanwhile, I just focused on low hanging fruit diet/exercise/sleep.
“Antioxidant supplements are not associated with lower all-cause mortality. Beta carotene, vitamin E, and higher doses of vitamin A may be associated with higher all-cause mortality. Therefore, our review does not support the use of antioxidant supplements as a primary or a secondary preventive measure.”
I took a very long break from the thing but am going back on it to see empagliflozin, semaglutide, and fruit effects
25mg empagliflozin 12 hr ago did not prevent a peak of 240 calories diced tomatoes from raising BG to 148. And these are just diced tomatoes…
The studies I have looked at show benefits for those who already have type II diabetes or already have some forms of CVD, but there is not much info on it having much of a preventative effect.
I have been taking it for about 5 months and have noticed zero effect on my fasting glucose. And, you are right it does not seem to prevent spikes. When my current supply runs out I don’t think I will order it again.
I am currently taking acarbose for its longevity promise and for preventing glucose spikes and I have been taking metformin for decades for both its longevity properties and blood glucose control. Acarbose definitely reduces glucose spikes but has had zero effect on my fasting glucose.