Finally some good news when it comes to alcohol 
Drink alcohol, socialize a lot, make lots of money, and use that money to live longer (you may even use that money for medicines to counter the effects of alcohol)
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Even better when drinking in youth take Pantethine at the same time as drinking.
The report, however, is as is often the case full of confounders.
Interestingly I am intending to award a couple of prizes at the talk on Thursday. I suggested some cash for a “drink”, but the organisers have asked me not to encourage alcohol drinking, but suggested chocolates and my response was that the glycemic index was probably too high for normal chocolates although dark chocolate would be OK.
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Was there anything else besides pantethine that could theoretically reduce the harms of alcohol?
Not just theoretically, but Molybdenum (be careful on this because it can increase urate), DHM, Bae, Melatonin, probably Copper and Iron as well.
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Not just theoretically, but Molybdenum (be careful on this because it can increase urate), DHM, Bae, Melatonin, probably Copper and Iron as well.
How much? Let’s assume you drink one bottle of wine over the course of an evening. And can you recommend good supplement brands?
Its interesting… you go to Christmas parties now in the SF Bay Area and frequently people are hardly drinking any alcohol at all, and this is even more prevalent in the younger age groups.
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How binge drinking triggers gut damage and inflammation so quickly
Research shows that a single drinking binge—roughly four drinks for women or five for men within about two hours—can disrupt the gastrointestinal tract in measurable ways. Even in healthy adults, such a rapid influx of alcohol can weaken the gut lining, making it less able to perform one of its core jobs: keeping bacteria and toxins from entering the bloodstream, a phenomenon known as “leaky gut.”
Now, investigators at Beth Israel Deaconess Medical Center (BIDMC) have identified how binge drinking damages the gut, and why those leaks in the system may set off harmful inflammation long after the last drink is poured. The findings are published in Alcohol: Clinical and Experimental Research.
How binge drinking affects the gut
Led by first author Scott Minchenberg, MD, Ph.D., a clinical fellow in gastroenterology and hepatology at BIDMC, the scientists examined how short bursts of high-dose alcohol affected different parts of the gut. Their findings suggested that even brief episodes of heavy drinking cause injury, calling in cells normally reserved for fighting invading germs to the lining of the gut.
Certain immune cells, called neutrophils, can release web-like structures known as NETs that directly damage the upper small intestine and weaken its barrier, helping explain the “leaky gut” that can let bacterial toxins slip into the bloodstream.
https://medicalxpress.com/news/2026-01-binge-triggers-gut-inflammation-quickly.html
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This really stood out to me - “Even consumption below one standard drink per day, or less than 10 grams of pure alcohol, was associated with elevated risk for cancers of the pharynx, colorectum, esophagus, breast, liver, pancreas, and prostate.”
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Since I started wearing an Oura ring several years ago, I have stopped all alcohol consumption except for a very rare glass of wine when on vacations. Oura makes it perfectly obvious in numerical terms how damaging alcohol is to sleep and overall health.
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Makes sense! I did the same - no alcohol besides may be 4 oz of red wine on very rare occasions.
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I found a bottle of sweet red wine with an ABV of only 5%. Lightly carbonated like a lambrusco, it gives me the illusion of drinking.
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I have found some of the new non-alcoholic beers to be just as good as the real craft beers.
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Well at 5% actually it isn’t much of an illusion, rather you are definitely consuming alcohol LOL. Plus, the fact it is loaded with sugar and before you know it not only, you’d be drunk but with diabetes to boot. LOL
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I would like to know a brand if you happened to have one, because all the ones I tried, I’d rather drink piss (if I can’t have real deal)LOL.
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No accounting for taste.
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And other good news…
Can You Reverse Decades of Drinking Damage? Perhaps. - EP 75 Jacob Kimmel Is Back
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https://www.rapamycin.news/t/alcohol-consumption/1235/251
Hope that worked. Hard ketones, you get the buzz and not the side effects.
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