Finally some good news when it comes to alcohol 
Drink alcohol, socialize a lot, make lots of money, and use that money to live longer (you may even use that money for medicines to counter the effects of alcohol)
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Even better when drinking in youth take Pantethine at the same time as drinking.
The report, however, is as is often the case full of confounders.
Interestingly I am intending to award a couple of prizes at the talk on Thursday. I suggested some cash for a “drink”, but the organisers have asked me not to encourage alcohol drinking, but suggested chocolates and my response was that the glycemic index was probably too high for normal chocolates although dark chocolate would be OK.
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Was there anything else besides pantethine that could theoretically reduce the harms of alcohol?
Not just theoretically, but Molybdenum (be careful on this because it can increase urate), DHM, Bae, Melatonin, probably Copper and Iron as well.
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Not just theoretically, but Molybdenum (be careful on this because it can increase urate), DHM, Bae, Melatonin, probably Copper and Iron as well.
How much? Let’s assume you drink one bottle of wine over the course of an evening. And can you recommend good supplement brands?
Its interesting… you go to Christmas parties now in the SF Bay Area and frequently people are hardly drinking any alcohol at all, and this is even more prevalent in the younger age groups.
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How binge drinking triggers gut damage and inflammation so quickly
Research shows that a single drinking binge—roughly four drinks for women or five for men within about two hours—can disrupt the gastrointestinal tract in measurable ways. Even in healthy adults, such a rapid influx of alcohol can weaken the gut lining, making it less able to perform one of its core jobs: keeping bacteria and toxins from entering the bloodstream, a phenomenon known as “leaky gut.”
Now, investigators at Beth Israel Deaconess Medical Center (BIDMC) have identified how binge drinking damages the gut, and why those leaks in the system may set off harmful inflammation long after the last drink is poured. The findings are published in Alcohol: Clinical and Experimental Research.
How binge drinking affects the gut
Led by first author Scott Minchenberg, MD, Ph.D., a clinical fellow in gastroenterology and hepatology at BIDMC, the scientists examined how short bursts of high-dose alcohol affected different parts of the gut. Their findings suggested that even brief episodes of heavy drinking cause injury, calling in cells normally reserved for fighting invading germs to the lining of the gut.
Certain immune cells, called neutrophils, can release web-like structures known as NETs that directly damage the upper small intestine and weaken its barrier, helping explain the “leaky gut” that can let bacterial toxins slip into the bloodstream.
https://medicalxpress.com/news/2026-01-binge-triggers-gut-inflammation-quickly.html
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