Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

#1
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Citrulline Glycine Lemonade
The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure
#2

For those of us with blood glucose control difficulties, this could be a great addition.

And a great word in that second article: splanchnic – of or relating to the viscera.

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#3

L-citrulline

stimulates protein synthesis in skeletal muscle through the mammalian target of rapamycin signaling pathway

There seem to be many papers on L-citrulline effects on muscular/vascular health including (via elicit.com)

L-citrulline, a precursor of nitric oxide, has been shown to enhance vascular function and muscle protein synthesis, particularly when combined with exercise training in older adults (Figueroa 2020).

Here is the full review article
[Sci-Hub | l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults. Exercise and Sport Sciences Reviews, 48(3), 133–139 | 10.1249/jes.0000000000000223]

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#4

My view, take L-citrulline and L-arginine supplementation, eat arugula*{has a high nitrate content] and take tadalafil 2.5mg dissolve under the tongue.{yes I allow to dissolve under the tongue]

Been doing just arugula, will be adding
L-citrulline and L-arginine supplementation

The tadalafil “kick starts” NOS.

Noninvasive assessment of endothelial function can be measured using an EndoPAT device.

*…The European Food Safety Authority (EFSA) has declared that arugula is an essential source of nitrate, with the highest nitrate concentration up to 6400 ppm"…
From:
https://doi.org/10.1016/j.meatsci.2022.109090

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#5

Be sure to avoid hypotension (low blood pressure) since both L-citrulline and tadalafil reduce blood pressure. I haven’t found any studies specifically evaluating the combined risk, but I’m also not sure why it’s necessary to take such an aggressive BP lowering stance if one is not hypertensive.

Same goes with combining L-citrulline with other BP lowering meds, approach with caution.

#6

This is why a lower blood pressure is important.

#7

We’re talking about hypotension with clear negative symptoms, such as dizziness and even fainting. This can be an issue for the elderly especially.

I applaud self-experimenters that weigh the benefits and risks, and take a measured approach to their trials. Seeing proposals that combine substances with potentially dangerous negative synergistic effects is concerning and should at least come with a warning (which is all I’m trying to do).

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#8

Another potential use of arginine is that it might prevent Alzheimer’s:

https://scitechdaily.com/scientists-discover-simple-supplement-that-could-help-slow-alzheimers/

Using in vitro assays, the researchers showed that arginine reduces the formation of Aβ42 aggregates, with stronger inhibition observed at higher concentrations. After confirming this effect in the lab, the team tested orally administered arginine in two well-known AD models:

  • A Drosophila model, expressing Aβ42 with the Arctic mutation (E22G)
  • An AppNL-G-F knock-in mouse model, carrying three familial AD mutations

In both models, arginine administration significantly reduced Aβ accumulation and alleviated Aβ-induced toxicity.

It might also regenerate the thymus:

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